The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: tripartite motif-containing protein 16

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O95361 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q99PP9 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q5R760 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O95361 (/IPI)
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
1 O95361 (/IPI)
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
1 Q99PP9 (/ISO)
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
1 Q5R760 (/ISS)
NACHT domain binding GO:0032089
Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.
1 O95361 (/IPI)
NACHT domain binding GO:0032089
Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.
1 Q99PP9 (/ISO)
NACHT domain binding GO:0032089
Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.
1 Q5R760 (/ISS)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 O95361 (/IEP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q5R760 (/ISS)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
1 O95361 (/IDA)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
1 Q99PP9 (/ISO)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
1 Q5R760 (/ISS)
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
1 O95361 (/IDA)
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
1 Q99PP9 (/ISO)
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
1 Q5R760 (/ISS)
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
1 O95361 (/IDA)
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
1 Q99PP9 (/ISO)
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
1 Q5R760 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 O95361 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q99PP9 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5R760 (/ISS)
Response to organophosphorus GO:0046683
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.
1 O95361 (/IEP)
Response to organophosphorus GO:0046683
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.
1 Q5R760 (/ISS)
Positive regulation of retinoic acid receptor signaling pathway GO:0048386
Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
1 O95361 (/IDA)
Positive regulation of retinoic acid receptor signaling pathway GO:0048386
Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
1 Q99PP9 (/ISO)
Positive regulation of retinoic acid receptor signaling pathway GO:0048386
Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
1 Q5R760 (/ISS)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 O95361 (/IMP)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 Q99PP9 (/ISO)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 Q5R760 (/ISS)
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
1 O95361 (/IDA)
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
1 Q99PP9 (/ISO)
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
1 Q5R760 (/ISS)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 B3KP96 (/IDA) O95361 (/IDA) Q309B1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 B3KP96 (/IDA) O95361 (/IDA) Q309B1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O95361 (/IDA) Q99PP9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99PP9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q5R760 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q99PP9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q99PP9 (/ISO)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
1 O95361 (/IDA)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
1 Q99PP9 (/ISO)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
1 Q5R760 (/ISS)
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