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CATH Superfamily 2.60.120.740

Rhamnose-binding lectin domain (RBL)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Rhamnose-binding lectin domain (RBL)

Latrophilins are adhesion G-protein-coupled receptors (adhesion GPCRs) and known receptors of alpha-latrotoxin, a neurotoxic component of black widow spider venom. Deficient Latrophilin3 expression is associated with attention-deficit hyperactivity disorder in humans. Vertebrate Latrophilin comprises of four domains: a rhamnose-binding lectin domain, olfactomedin-like domain (Olf), a glycosylated 100-residue linker and a GAIN domain PMID:27091502.

This entry represents the rhamnose-binding lectin domain (also known as the N-terminal lectin domain, Lec). RBL is composed of five beta-strands , a single, long alpha-helix, and two small helical elements. The overall fold is that of a beta-sandwich with two antiparallel sheets PMID:18547526.

PMID:27091502 PMID:18547526

GO Diversity

Unique GO annotations
81 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
708 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 25
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 2
Unique PDBs: 9
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 25
Function
Unique EC: 1
Unique GO: 81
Taxonomy
Unique Species: 708