The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cupin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 60: Histone demethylase JHD2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
2 P47156 (/IDA) P47156 (/IDA)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
2 P47156 (/IMP) P47156 (/IMP)
Histone demethylase activity (H3-monomethyl-K4 specific) GO:0034649
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 4) + O2 + FAD + H2O = histone H3 L-lysine (position 4) + H2O2 + formaldehyde + FADH2. This reaction is the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein.
2 P47156 (/IMP) P47156 (/IMP)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P47156 (/IMP) P47156 (/IMP)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
2 P47156 (/IMP) P47156 (/IMP)
Histone demethylation GO:0016577
The modification of histones by removal of methyl groups.
2 P47156 (/IDA) P47156 (/IDA)
Histone demethylation GO:0016577
The modification of histones by removal of methyl groups.
2 P47156 (/IMP) P47156 (/IMP)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
2 P47156 (/IMP) P47156 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P47156 (/IMP) P47156 (/IMP)
Regulation of chromosome condensation GO:0060623
Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
2 P47156 (/IMP) P47156 (/IMP)
Antisense RNA transcript catabolic process GO:0071041
The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product.
2 P47156 (/IMP) P47156 (/IMP)
Regulation of chromatin organization GO:1902275
Any process that modulates the frequency, rate or extent of chromatin organization.
2 P47156 (/IMP) P47156 (/IMP)
Negative regulation of ncRNA transcription associated with protein coding gene TSS/TES GO:1904388
Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES.
2 P47156 (/IMP) P47156 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P47156 (/HDA) P47156 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P47156 (/HDA) P47156 (/HDA)
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