The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cupin
".
FunFam 21: Lysine-specific demethylase 7A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 27 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
4 | P0CF52 (/ISS) Q08D35 (/ISS) Q3UWM4 (/ISS) Q5RHD1 (/ISS) |
|
Histone demethylase activity (H4-K20 specific) GO:0035575
Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.
|
4 | P0CF52 (/ISS) Q08D35 (/ISS) Q3UWM4 (/ISS) Q5RHD1 (/ISS) |
|
Histone demethylase activity (H3-K36 specific) GO:0051864
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.
|
4 | P0CF52 (/ISS) Q08D35 (/ISS) Q3UWM4 (/ISS) Q5RHD1 (/ISS) |
|
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
|
3 | P0CF52 (/IDA) Q5RHD1 (/IDA) Q6ZMT4 (/IDA) |
|
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
|
3 | P0CF52 (/ISS) Q08D35 (/ISS) Q5RHD1 (/ISS) |
|
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
|
3 | P0CF52 (/IDA) Q5RHD1 (/IDA) Q6ZMT4 (/IDA) |
|
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
|
3 | P0CF52 (/ISS) Q08D35 (/ISS) Q5RHD1 (/ISS) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
2 | Q08D35 (/ISS) Q3UWM4 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q08D35 (/ISS) Q3UWM4 (/ISS) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
2 | Q08D35 (/ISS) Q3UWM4 (/ISS) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | Q6ZMT4 (/IDA) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | Q3UWM4 (/ISO) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | Q6ZMT4 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q6ZMT4 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q3UWM4 (/ISO) |
|
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | Q6ZMT4 (/IDA) |
|
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | Q3UWM4 (/ISO) |
|
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
|
1 | Q3UWM4 (/IMP) |
|
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
|
1 | Q3UWM4 (/ISO) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q6ZMT4 (/IDA) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q3UWM4 (/ISO) |
|
Histone demethylase activity (H4-K20 specific) GO:0035575
Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.
|
1 | Q6ZMT4 (/IDA) |
|
Histone demethylase activity (H4-K20 specific) GO:0035575
Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.
|
1 | Q3UWM4 (/ISO) |
|
Histone demethylase activity (H3-K36 specific) GO:0051864
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.
|
1 | Q6ZMT4 (/IDA) |
|
Histone demethylase activity (H3-K36 specific) GO:0051864
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.
|
1 | Q3UWM4 (/ISO) |
|
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
|
1 | Q3UWM4 (/IMP) |
|
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
|
1 | Q3UWM4 (/ISO) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone H4-K20 demethylation GO:0035574
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.
|
4 | P0CF52 (/ISS) Q08D35 (/ISS) Q3UWM4 (/ISS) Q5RHD1 (/ISS) |
|
Histone H3-K36 demethylation GO:0070544
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
|
4 | P0CF52 (/ISS) Q08D35 (/ISS) Q3UWM4 (/ISS) Q5RHD1 (/ISS) |
|
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
3 | Q08D35 (/ISS) Q3UWM4 (/ISS) Q6ZMT4 (/ISS) |
|
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
|
3 | P0CF52 (/IDA) Q5RHD1 (/IDA) Q6ZMT4 (/IDA) |
|
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
|
3 | P0CF52 (/ISS) Q08D35 (/ISS) Q5RHD1 (/ISS) |
|
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
|
3 | P0CF52 (/IDA) Q5RHD1 (/IDA) Q6ZMT4 (/IDA) |
|
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
|
3 | P0CF52 (/ISS) Q08D35 (/ISS) Q5RHD1 (/ISS) |
|
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
2 | P0CF52 (/IGI) Q5RHD1 (/IGI) |
|
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
2 | P0CF52 (/IMP) Q5RHD1 (/IMP) |
|
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
|
1 | Q3UWM4 (/IMP) |
|
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
|
1 | Q3UWM4 (/ISO) |
|
Histone H4-K20 demethylation GO:0035574
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.
|
1 | Q6ZMT4 (/IDA) |
|
Histone H4-K20 demethylation GO:0035574
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.
|
1 | Q3UWM4 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q3UWM4 (/IMP) |
|
Histone H3-K36 demethylation GO:0070544
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
|
1 | Q6ZMT4 (/IDA) |
|
Histone H3-K36 demethylation GO:0070544
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
|
1 | Q3UWM4 (/ISO) |
|
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
|
1 | Q3UWM4 (/IMP) |
|
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
|
1 | Q3UWM4 (/ISO) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q6ZMT4 (/IC) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q6ZMT4 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q3UWM4 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q6ZMT4 (/TAS) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q6ZMT4 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q3UWM4 (/ISO) |
