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CATH Superfamily 2.60.120.590

Alpha-ketoglutarate-dependent dioxygenase AlkB-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: AlkB homolog 1, histone H2A dioxygenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA N(6)-methyladenine demethylase. [EC: 1.14.11.51]
N(6)-methyladenine in DNA + 2-oxoglutarate + O(2) = adenine in DNA + formaldehyde + succinate + CO(2).
  • Catalyzes oxidative demethylation of DNA N(6)-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
 2 P0CB42 Q13686
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
 2 P0CB42 Q13686
DNA oxidative demethylase. [EC: 1.14.11.33]
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
  • Activity is slightly stimulated by ascorbate.
  • Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine.
  • It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
 2 P0CB42 Q13686