The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: FTO, alpha-ketoglutarate dependent dioxygenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
5 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS)
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
5 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q8BGW1 (/ISS)
Oxidative RNA demethylase activity GO:0035515
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS)
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS)
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS)
Oxidative RNA demethylase activity GO:0035515
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 Q9C0B1 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 Q8BGW1 (/ISO)
Oxidative RNA demethylase activity GO:0035515
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
1 Q8BGW1 (/ISO)
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
1 Q8BGW1 (/ISO)
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
1 Q8BGW1 (/ISO)
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
1 Q9C0B1 (/IDA)
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
1 Q9C0B1 (/IMP)
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
1 Q8BGW1 (/ISO)
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
1 Q9C0B1 (/IDA)
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
1 Q8BGW1 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
5 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS)
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q8BGW1 (/ISS)
Oxidative single-stranded DNA demethylation GO:0035552
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS)
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
4 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS)
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Regulation of lipid storage GO:0010883
Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
2 Q8BGW1 (/IMP) Q9C0B1 (/IMP)
Oxidative single-stranded DNA demethylation GO:0035552
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
RNA repair GO:0042245
Any process that results in the repair of damaged RNA.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
2 A0A2R8PY24 (/IMP) F1R5T4 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
2 A0A2R8PY24 (/IMP) F1R5T4 (/IMP)
Left/right pattern formation GO:0060972
The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
2 A0A2R8PY24 (/IMP) F1R5T4 (/IMP)
Oxidative demethylation GO:0070989
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 A0A2R8PY24 (/IMP) F1R5T4 (/IMP)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 Q8BGW1 (/IMP)
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
1 Q8BGW1 (/ISO)
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
1 Q9C0B1 (/TAS)
Regulation of lipid storage GO:0010883
Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 Q8BGW1 (/ISO)
Oxidative single-stranded DNA demethylation GO:0035552
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
1 Q8BGW1 (/ISO)
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
1 Q9C0B1 (/IMP)
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
1 Q8BGW1 (/ISO)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q8BGW1 (/IMP)
RNA repair GO:0042245
Any process that results in the repair of damaged RNA.
1 Q8BGW1 (/ISO)
Regulation of respiratory system process GO:0044065
Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.
1 Q8BGW1 (/IMP)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
1 Q8BGW1 (/IMP)
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
1 Q9C0B1 (/IDA)
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
1 Q8BGW1 (/ISO)
Regulation of white fat cell proliferation GO:0070350
Any process that modulates the frequency, rate or extent of white fat cell proliferation.
1 Q8BGW1 (/IMP)
Oxidative demethylation GO:0070989
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
1 Q8BGW1 (/ISO)
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
1 Q8BGW1 (/ISO)
Regulation of brown fat cell differentiation GO:0090335
Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 Q9C0B1 (/IMP)
Regulation of brown fat cell differentiation GO:0090335
Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 Q8BGW1 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q9C0B1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
5 Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8BGW1 (/IDA) Q9C0B1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BGW1 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9C0B1 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9C0B1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BGW1 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q9C0B1 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q8BGW1 (/ISO)
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