The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 8: Tumor necrosis factor ligand superfamily member 11

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O14788 (/IPI) O14788 (/IPI) O35235 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
2 O14788 (/IDA) O14788 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
2 O14788 (/NAS) O14788 (/NAS)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
2 O14788 (/NAS) O14788 (/NAS)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
2 O14788 (/IC) O14788 (/IC)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 O35235 (/ISO)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
1 O35235 (/IPI)

There are 71 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
3 O14788 (/ISS) O14788 (/ISS) Q9ESE2 (/ISS)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
3 O14788 (/IDA) O14788 (/IDA) O35235 (/IDA)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
3 O14788 (/IDA) O14788 (/IDA) O35235 (/IDA)
TNFSF11-mediated signaling pathway GO:0071847
A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O14788 (/IDA) O14788 (/IDA) O35235 (/IDA)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
2 O14788 (/IDA) O14788 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 O14788 (/NAS) O14788 (/NAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O14788 (/IDA) O14788 (/IDA)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 O14788 (/ISS) O14788 (/ISS)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 O14788 (/NAS) O14788 (/NAS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O14788 (/ISS) O14788 (/ISS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O14788 (/TAS) O14788 (/TAS)
Positive regulation of homotypic cell-cell adhesion GO:0034112
Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 O14788 (/ISS) O14788 (/ISS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of corticotropin-releasing hormone secretion GO:0051466
Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.
2 O14788 (/ISS) O14788 (/ISS)
Positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812
Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.
2 O14788 (/ISS) O14788 (/ISS)
Positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848
Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade.
2 O14788 (/IDA) O14788 (/IDA)
Positive regulation of intracellular signal transduction GO:1902533
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
2 O14788 (/IDA) O14788 (/IDA)
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 O35235 (/IMP)
Osteoclast proliferation GO:0002158
The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.
1 O35235 (/IDA)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
1 O35235 (/ISO)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
1 O35235 (/IDA)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
1 Q9ESE2 (/IEP)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 O35235 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O35235 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O35235 (/ISO)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 O35235 (/IDA)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 O35235 (/IGI)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 O35235 (/IMP)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 O35235 (/ISO)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O35235 (/IGI)
Mammary gland epithelial cell proliferation GO:0033598
The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
1 O35235 (/IMP)
Positive regulation of homotypic cell-cell adhesion GO:0034112
Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion.
1 O35235 (/ISO)
Response to immobilization stress GO:0035902
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.
1 Q9ESE2 (/IEP)
Osteoclast development GO:0036035
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 O35235 (/IDA)
Paracrine signaling GO:0038001
The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.
1 O35235 (/IDA)
Positive regulation of phosphorylation GO:0042327
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
1 O35235 (/IDA)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 O35235 (/IDA)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 O35235 (/ISO)
Tooth eruption GO:0044691
The tooth development process in which the teeth enter the mouth and become visible.
1 O35235 (/IMP)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
1 O35235 (/IDA)
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
1 O35235 (/IDA)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
1 O35235 (/IGI)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
1 Q9ESE2 (/IMP)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
1 O35235 (/ISO)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 Q9ESE2 (/IMP)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 O35235 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O35235 (/ISO)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 O35235 (/IGI)
Lymph node development GO:0048535
The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
1 O35235 (/TAS)
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
1 O35235 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O35235 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 O35235 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 O35235 (/IDA)
Positive regulation of corticotropin-releasing hormone secretion GO:0051466
Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.
1 O35235 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 O35235 (/IMP)
Calcium ion homeostasis GO:0055074
Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
1 O35235 (/IGI)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
1 O35235 (/IMP)
Mammary gland alveolus development GO:0060749
The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.
1 O35235 (/IMP)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
1 O35235 (/IDA)
Positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812
Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.
1 O35235 (/IDA)
TNFSF11-mediated signaling pathway GO:0071847
A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O35235 (/ISO)
Positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848
Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade.
1 O35235 (/ISO)
Positive regulation of intracellular signal transduction GO:1902533
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
1 O35235 (/ISO)
Regulation of actin binding GO:1904616
Any process that modulates the frequency, rate or extent of actin binding.
1 O35235 (/IDA)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 O35235 (/IEP)
Positive regulation of osteoclast development GO:2001206
Any process that activates or increases the frequency, rate or extent of osteoclast development.
1 O35235 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O14788 (/NAS) O14788 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O14788 (/TAS) O14788 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O14788 (/TAS) O14788 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 O14788 (/NAS) O14788 (/NAS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...