The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: complement C1q tumor necrosis factor-related prote...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
3 Q9BXJ4 (/IDA) Q9ES30 (/IDA) Q9ES30 (/IDA)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
3 Q9BXJ4 (/IDA) Q9ES30 (/IDA) Q9ES30 (/IDA)
Positive regulation of adiponectin secretion GO:0070165
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.
3 Q9BXJ4 (/IDA) Q9ES30 (/IDA) Q9ES30 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Cellular triglyceride homeostasis GO:0035356
Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)
Positive regulation of adiponectin secretion GO:0070165
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Protein trimerization GO:0070206
The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
2 Q9ES30 (/ISO) Q9ES30 (/ISO)
Cellular triglyceride homeostasis GO:0035356
Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment.
1 Q9BXJ4 (/IDA)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
1 Q9BXJ4 (/IEP)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 Q9BXJ4 (/IDA)
Protein trimerization GO:0070206
The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.
1 Q9BXJ4 (/IDA)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
1 Q9BXJ4 (/IDA)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 Q9BXJ4 (/IDA)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q9BXJ4 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q9ES30 (/IDA) Q9ES30 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9BXJ4 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9BXJ4 (/HDA)
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