The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39: Tumor necrosis factor (Ligand) superfamily member ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
4 P43488 (/IPI) P43488 (/IPI) Q9Z2P3 (/IPI) Q9Z2P3 (/IPI)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
2 P43488 (/IPI) P43488 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P43488 (/IPI) P43488 (/IPI)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
2 Q9Z2P3 (/IMP) Q9Z2P3 (/IMP)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
2 P43488 (/ISO) P43488 (/ISO)

There are 68 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
2 P43488 (/NAS) P43488 (/NAS)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q9Z2P3 (/IMP) Q9Z2P3 (/IMP)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P43488 (/ISO) P43488 (/ISO)
Defense response to nematode GO:0002215
A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
2 P43488 (/IMP) P43488 (/IMP)
Acute inflammatory response GO:0002526
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of immune effector process GO:0002699
Any process that activates or increases the frequency, rate, or extent of an immune effector process.
2 P43488 (/TAS) P43488 (/TAS)
Positive regulation of T cell cytokine production GO:0002726
Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
2 P43488 (/IDA) P43488 (/IDA)
Regulation of adaptive immune response GO:0002819
Any process that modulates the frequency, rate, or extent of an adaptive immune response.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of type 2 immune response GO:0002830
Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of type 2 immune response GO:0002830
Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of immunoglobulin mediated immune response GO:0002891
Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
2 P43488 (/IMP) P43488 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 P43488 (/IPI) P43488 (/IPI)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2 P43488 (/IMP) P43488 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 P43488 (/IDA) P43488 (/IDA)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P43488 (/IDA) P43488 (/IDA)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
2 P43488 (/ISO) P43488 (/ISO)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
2 P43488 (/ISS) P43488 (/ISS)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P43488 (/ISO) P43488 (/ISO)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of interleukin-13 production GO:0032736
Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
2 Q9Z2P3 (/IDA) Q9Z2P3 (/IDA)
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
2 P43488 (/ISO) P43488 (/ISO)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
2 P43488 (/ISO) P43488 (/ISO)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2 P43488 (/ISO) P43488 (/ISO)
Memory T cell activation GO:0035709
The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P43488 (/IMP) P43488 (/IMP)
T-helper 2 cell activation GO:0035712
The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P43488 (/IMP) P43488 (/IMP)
Response to nitrogen dioxide GO:0035713
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.
2 P43488 (/IDA) P43488 (/IDA)
Cellular response to nitrogen dioxide GO:0035714
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.
2 P43488 (/IMP) P43488 (/IMP)
CD4-positive, alpha-beta T cell costimulation GO:0035783
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.
2 P43488 (/IDA) P43488 (/IDA)
T cell proliferation GO:0042098
The expansion of a T cell population by cell division. Follows T cell activation.
2 Q9Z2P3 (/IMP) Q9Z2P3 (/IMP)
T cell proliferation GO:0042098
The expansion of a T cell population by cell division. Follows T cell activation.
2 P43488 (/ISO) P43488 (/ISO)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
2 Q9Z2P3 (/IDA) Q9Z2P3 (/IDA)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
2 P43488 (/ISO) P43488 (/ISO)
Positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of memory T cell differentiation GO:0043382
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
2 P43488 (/IDA) P43488 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P43488 (/IDA) P43488 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 P43488 (/NAS) P43488 (/NAS)
Negative regulation of regulatory T cell differentiation GO:0045590
Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.
2 P43488 (/IMP) P43488 (/IMP)
Negative regulation of T-helper 1 cell differentiation GO:0045626
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of T-helper 2 cell differentiation GO:0045630
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.
2 P43488 (/IDA) P43488 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
2 P43488 (/IMP) P43488 (/IMP)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P43488 (/IPI) P43488 (/IPI)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 P43488 (/ISO) P43488 (/ISO)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 P43488 (/ISS) P43488 (/ISS)
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
2 P43488 (/IDA) P43488 (/IDA)
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
2 P43488 (/IC) P43488 (/IC)
Negative regulation of activation-induced cell death of T cells GO:0070236
Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.
2 P43488 (/IC) P43488 (/IC)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P43488 (/ISO) P43488 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P43488 (/ISS) P43488 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P43488 (/NAS) P43488 (/NAS)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
2 P43488 (/ISO) P43488 (/ISO)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
2 P43488 (/ISS) P43488 (/ISS)
Chemokine (C-C motif) ligand 11 production GO:0071954
The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of CD4-positive, alpha-beta T cell costimulation GO:1900281
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
2 P43488 (/NAS) P43488 (/NAS)
Positive regulation of T cell costimulation GO:2000525
Any process that activates or increases the frequency, rate or extent of T cell costimulation.
2 P43488 (/IDA) P43488 (/IDA)
Positive regulation of memory T cell activation GO:2000568
Any process that activates or increases the frequency, rate or extent of memory T cell activation.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of T-helper 2 cell activation GO:2000570
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.
2 P43488 (/IMP) P43488 (/IMP)
Positive regulation of interleukin-4-dependent isotype switching to IgE isotypes GO:2000572
Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes.
2 P43488 (/IMP) P43488 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
2 P43488 (/IC) P43488 (/IC)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P43488 (/ISO) P43488 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P43488 (/ISS) P43488 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9Z2P3 (/IDA) Q9Z2P3 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P43488 (/ISO) P43488 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P43488 (/ISS) P43488 (/ISS)
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