The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Tumor necrosis factor ligand superfamily member 18

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q7TS55 (/IPI) Q9UNG2 (/IPI) Q9UNG2 (/IPI) Q9UNG2 (/IPI) Q9UNG2 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 Q7TS55 (/IPI) Q9UNG2 (/IPI) Q9UNG2 (/IPI) Q9UNG2 (/IPI) Q9UNG2 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
4 Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
1 Q7TS55 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q7TS55 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
5 Q7TS55 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP)
T cell proliferation involved in immune response GO:0002309
The expansion of a T cell population by cell division as part of an immune response.
4 Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
4 Q9UNG2 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
4 Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS)
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
4 Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
4 Q9UNG2 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP) Q9UNG2 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
4 Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
4 Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS)
Response to molecule of bacterial origin GO:0002237
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
1 Q4W897 (/IDA)
T cell proliferation involved in immune response GO:0002309
The expansion of a T cell population by cell division as part of an immune response.
1 Q7TS55 (/IDA)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
1 Q7TS55 (/ISO)
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
1 Q7TS55 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q4W897 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q7TS55 (/IMP)
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
1 Q7TS55 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 Q7TS55 (/ISO)
Response to exogenous dsRNA GO:0043330
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
1 Q4W897 (/IDA)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q7TS55 (/ISO)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q7TS55 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q7TS55 (/IMP)
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
1 Q7TS55 (/IMP)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q7TS55 (/IMP)
Negative regulation of T-helper 17 cell lineage commitment GO:2000329
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment.
1 Q7TS55 (/IMP)
Regulation of dendritic cell chemotaxis GO:2000508
Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis.
1 Q7TS55 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS) Q9UNG2 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS) Q9UNG2 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q7TS55 (/IDA)
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