The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 25: tumor necrosis factor ligand superfamily member 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
5 P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P23510 (/IPI) P23510 (/IPI) P23510 (/IPI) P23510 (/IPI) P23510 (/IPI)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to nematode GO:0002215
A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Acute inflammatory response GO:0002526
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of T cell cytokine production GO:0002726
Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Regulation of adaptive immune response GO:0002819
Any process that modulates the frequency, rate, or extent of an adaptive immune response.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of type 2 immune response GO:0002830
Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of immunoglobulin mediated immune response GO:0002891
Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of interleukin-13 production GO:0032736
Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS)
Memory T cell activation GO:0035709
The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
T-helper 2 cell activation GO:0035712
The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Response to nitrogen dioxide GO:0035713
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of memory T cell differentiation GO:0043382
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Negative regulation of regulatory T cell differentiation GO:0045590
Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Negative regulation of T-helper 1 cell differentiation GO:0045626
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of T-helper 2 cell differentiation GO:0045630
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Chemokine (C-C motif) ligand 11 production GO:0071954
The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of CD4-positive, alpha-beta T cell costimulation GO:1900281
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)
Positive regulation of interleukin-4-dependent isotype switching to IgE isotypes GO:2000572
Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes.
5 P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS) P23510 (/ISS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P23510 (/NAS) P23510 (/NAS) P23510 (/NAS) P23510 (/NAS) P23510 (/NAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS) P23510 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA) P23510 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...