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CATH Superfamily 2.60.120.330

B-lactam Antibiotic, Isopenicillin N Synthase; Chain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
B-lactam Antibiotic, Isopenicillin N Synthase; Chain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Flavonol synthase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Anthocyanidin synthase. [EC: 1.14.20.4]
A (2R,3S,4S)-leucoanthocyanidin + 2-oxoglutarate + O(2) = an anthocyanidin + succinate + CO(2) + 2 H(2)O.
  • Is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins).
  • Hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol.
  • The product loses a second water molecule to form anthocyanidins.
  • When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols.
  • Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed.
  • The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.20.6).
  • Formerly EC 1.14.11.19.
 11 A0A1Q0ZSU2 A0A1Q0ZSU2 A2WQ39 P41213 P41213 Q0WWD6 Q0WWD6 Q67VR7 Q93VC3 Q96323
(1 more...)
Flavonol synthase. [EC: 1.14.20.6]
A dihydroflavonol + 2-oxoglutarate + O(2) = a flavonol + succinate + CO(2) + H(2)O.
  • In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from the satsuma Citrus unshiu also has a non- specific activity that trans-hydroxylates the flavanones (2S)- naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively.
  • Formerly EC 1.14.11.23.
 10 A0A384L0E6 A0A384L0E6 A0A384L0E6 B1GV57 B1GV57 B1GV57 Q96330 Q96330 Q96330 Q9FFQ5
Flavanone 3-dioxygenase. [EC: 1.14.11.9]
A (2S)-flavan-4-one + 2-oxoglutarate + O(2) = a (2R,3R)-dihydroflavonol + succinate + CO(2).
  • This plant enzyme catalyzes an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins.
  • Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)- dihydrotricetin and (2S)-pinocembrin.
  • Some enzymes are bifuctional and also catalyze EC 1.14.20.6.
 9 A0A384L0E6 A0A384L0E6 A0A384L0E6 B1GV57 B1GV57 B1GV57 Q96330 Q96330 Q96330