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CATH Superfamily 2.60.120.330

B-lactam Antibiotic, Isopenicillin N Synthase; Chain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
B-lactam Antibiotic, Isopenicillin N Synthase; Chain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Feruloyl CoA ortho-hydroxylase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Feruloyl-CoA 6-hydroxylase. [EC: 1.14.11.61]
Trans-feruloyl-CoA + 2-oxoglutarate + O(2) = trans-6-hydroxy-feruloyl-CoA + succinate + CO(2).
  • Requires iron(II) and ascorbate.
  • The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process.
  • The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA.
  • Cf. EC 1.14.11.62.
 17 A0A023GS28 A0A023GS29 A0A178V671 A0A178V671 A0A178WBY8 A0A178WBY8 G9M9M0 G9M9M1 G9M9M2 G9M9M3
(7 more...)
Trans-4-coumaroyl-CoA 2'-hydroxylase. [EC: 1.14.11.62]
Trans-4-coumaroyl-CoA + 2-oxoglutarate + O(2) = 2,4-dihydroxy-trans- cinnamoyl-CoA + succinate + CO(2).
  • Requires iron(II) and ascorbate.
  • The product spontaneously undergoes trans-cis isomerization followed by lactonization and cyclization, liberating CoA and forming umbelliferone.
  • The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-feruloyl-CoA (cf. EC 1.14.11.61).
 6 A0A023GS28 A0A023GS29 G9M9M3 G9M9M4 G9M9M5 W5QJZ5
Scopoletin 8-hydroxylase. [EC: 1.14.11.60]
Scopoletin + 2-oxoglutarate + O(2) = fraxetin + succinate + CO(2).
  • Requires iron(II) and ascorbate.
  • A protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
 4 A0A384KU43 A0A384KU43 Q9LE86 Q9LE86
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