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CATH Superfamily 2.60.120.10

Jelly Rolls

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 42: Hypoxia-inducible factor 1-alpha inhibitor

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hypoxia-inducible factor-asparagine dioxygenase. [EC: 1.14.11.30]
Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) = hypoxia- inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2).
  • Contains iron, and requires ascorbate.
  • Catalyzes hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300.
  • The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
 66 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A0D9QZU0 A0A0D9QZU0
(56 more...)
Ankyrin-repeat-histidine dioxagenase. [EC: 1.14.11.n4]
(1) [Ankyrin-repeat domain protein]-L-histidine + 2-oxoglutarate + O(2) = [ankyrin-repeat domain protein]-(3S)-3-hydroxy-L-histidine + succinate + CO(2). (2) [Ankyrin-repeat domain protein]-L-asparagine + 2-oxoglutarate + O(2) = [ankyrin-repeat domain protein]-(3S)-3-hydroxy-L-asparagine + succinate + CO(2). (3) [Ankyrin-repeat domain protein]-L-aspartate + 2-oxoglutarate + O(2) = [ankyrin-repeat domain protein]-(3S)-3-hydroxy-L-aspartate + succinate + CO(2).
    		 66 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A096P694 A0A0D9QZU0 A0A0D9QZU0
    (56 more...)
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