The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Jelly Rolls
".
FunFam 40: rap guanine nucleotide exchange factor 6 isoform X...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | G5EDB9 (/IPI) Q8TEU7 (/IPI) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q8TEU7 (/IDA) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q9UHV4 (/ISS) |
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
1 | Q8TEU7 (/IDA) |
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | G5EDB9 (/IDA) |
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
|
1 | Q8TEU7 (/IDA) |
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
|
1 | Q9UHV4 (/ISS) |
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
|
1 | Q8TEU7 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Microvillus assembly GO:0030033
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
1 | Q8TEU7 (/NAS) |
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
1 | G5EDB9 (/IMP) |
Molting cycle, collagen and cuticulin-based cuticle GO:0018996
The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans.
|
1 | G5EDB9 (/IMP) |
Microvillus assembly GO:0030033
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
|
1 | Q8TEU7 (/IGI) |
Collagen and cuticulin-based cuticle development GO:0040002
Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans.
|
1 | G5EDB9 (/IMP) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q8TEU7 (/NAS) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
1 | Q8TEU7 (/IMP) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
1 | Q8TEU7 (/IMP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
|
7 | B2RUJ6 (/ISO) Q3TKC6 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ2 (/ISO) Q8BLC8 (/ISO) Q8BX14 (/ISO) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
2 | E9PCH4 (/IDA) Q8TEU7 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | E9PCH4 (/IDA) Q8TEU7 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8TEU7 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9UHV4 (/ISS) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q8TEU7 (/IDA) |
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
|
1 | Q8TEU7 (/IDA) |
Collagen and cuticulin-based cuticle extracellular matrix GO:0060102
A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.
|
1 | G5EDB9 (/IDA) |