The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 166: blood vessel epicardial substance isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Retina layer formation GO:0010842
The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Skeletal myofibril assembly GO:0014866
The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Cell-cell junction organization GO:0045216
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Epithelium development GO:0060429
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Establishment of skin barrier GO:0061436
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Epiboly GO:0090504
The expansion of one cell sheet over other cells or yolk.
2 Q5PQZ7 (/IMP) Q5PQZ7 (/IMP)
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
1 Q8JH92 (/IDA)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 Q8JH92 (/IDA)
Regulation of cell-cell adhesion involved in gastrulation GO:0070587
Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation.
1 Q8JH92 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
3 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS) Q8JH92 (/ISS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 Q5PQZ7 (/IDA) Q5PQZ7 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 Q5PQZ7 (/ISS) Q5PQZ7 (/ISS)
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