The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: DNA damage inducible 1 homolog 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q5TDH0 (/IPI) Q5TDH0 (/IPI) Q5TDH0 (/IPI) Q5TDH0 (/IPI) Q5TDH0 (/IPI) Q5TDH0 (/IPI) Q8WTU0 (/IPI)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
7 Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q9VXF9 (/IDA)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
6 Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
4 A2ADY9 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 A2ADY9 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
3 Q10256 (/IDA) Q1EBV4 (/IDA) Q1EBV4 (/IDA)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
1 Q10256 (/ISO)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
1 A2ADY9 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 A2ADY9 (/ISO)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 A2ADY9 (/ISO)
Proteasome binding GO:0070628
Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
1 Q9VXF9 (/IPI)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
10 A0JPP7 (/ISS) A2ADY9 (/ISS) Q2T9Z1 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q9DAF3 (/ISS)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
10 A0JPP7 (/ISS) A2ADY9 (/ISS) Q2T9Z1 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q9DAF3 (/ISS)
Cellular response to hydroxyurea GO:0072711
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
10 A0JPP7 (/ISS) A2ADY9 (/ISS) Q2T9Z1 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q9DAF3 (/ISS)
Regulation of DNA stability GO:0097752
Any process that modulates the stability of DNA.
10 A0JPP7 (/ISS) A2ADY9 (/ISS) Q2T9Z1 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q95JI3 (/ISS) Q9DAF3 (/ISS)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
7 Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q8WTU0 (/IMP)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
7 Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q8WTU0 (/IMP)
Cellular response to hydroxyurea GO:0072711
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
7 Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q8WTU0 (/IMP)
Regulation of DNA stability GO:0097752
Any process that modulates the stability of DNA.
7 Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q8WTU0 (/IMP)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
6 Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
6 Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP) Q5TDH0 (/IMP)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
4 A2ADY9 (/ISS) Q497D6 (/ISS) Q6TH22 (/ISS) Q7ZYA7 (/ISS)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
2 A2ADY9 (/ISO) Q9DAF3 (/ISO)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2 A2ADY9 (/ISO) Q9DAF3 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 Q1EBV4 (/IEP) Q1EBV4 (/IEP)
Cellular response to hydroxyurea GO:0072711
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
2 A2ADY9 (/ISO) Q9DAF3 (/ISO)
Regulation of DNA stability GO:0097752
Any process that modulates the stability of DNA.
2 A2ADY9 (/ISO) Q9DAF3 (/ISO)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q54JB0 (/ISS)
Female germline ring canal formation GO:0007301
Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
1 Q9VXF9 (/IMP)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 A2ADY9 (/ISO)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
1 Q10256 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q10256 (/TAS)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 Q1EBV4 (/IDA) Q1EBV4 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA) Q5TDH0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q1EBV4 (/IDA) Q1EBV4 (/IDA) Q9VXF9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9VXF9 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 A2ADY9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9VXF9 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9VXF9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9VXF9 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A2ADY9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q10256 (/ISO)
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