The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: A-kinase anchor protein 1, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O08715 (/IPI) Q92667 (/IPI) Q92667 (/IPI)
Protein kinase A regulatory subunit binding GO:0034237
Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
3 E7FLX9 (/IPI) Q92667 (/IPI) Q92667 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q92667 (/HDA) Q92667 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q92667 (/TAS) Q92667 (/TAS)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 O88884 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 O08715 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O88884 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O88884 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O08715 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 O88884 (/IDA)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 O08715 (/ISO)
Protein phosphatase 2B binding GO:0030346
Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.
1 O88884 (/IDA)
Protein phosphatase 2B binding GO:0030346
Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.
1 O08715 (/ISO)
Protein kinase A regulatory subunit binding GO:0034237
Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
1 O88884 (/IDA)
Protein kinase A regulatory subunit binding GO:0034237
Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
1 O08715 (/ISO)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 O88884 (/IDA)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 O08715 (/ISO)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 O88884 (/IDA)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 O08715 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
2 Q92667 (/TAS) Q92667 (/TAS)
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
1 O88884 (/IMP)
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
1 O08715 (/ISO)
Regulation of protein kinase A signaling GO:0010738
Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
1 O88884 (/IC)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 E7FLX9 (/IMP)
Negative regulation of protein dephosphorylation GO:0035308
Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.
1 O88884 (/IMP)
Negative regulation of protein dephosphorylation GO:0035308
Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.
1 O08715 (/ISO)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
1 O88884 (/IMP)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
1 O08715 (/ISO)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 O88884 (/IEP)
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 O88884 (/IEP)
Positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146
Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
1 E7FLX9 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 A0A140VK05 (/IDA) A0A140VK05 (/IDA) Q92667 (/IDA) Q92667 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q92667 (/TAS) Q92667 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q92667 (/HDA) Q92667 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E7FLX9 (/IMP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O08715 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O08715 (/ISO)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 O08715 (/TAS)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 O88884 (/IDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 O08715 (/ISO)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
1 O88884 (/IDA)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
1 O08715 (/ISO)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 O88884 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 O08715 (/ISO)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 O88884 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 O08715 (/ISO)