CATH Superfamily 2.40.50.40
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 6: Chromobox protein homolog 7
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
20 |
O00257 (/IPI)
O00257 (/IPI)
O00257 (/IPI)
O55187 (/IPI)
O95503 (/IPI)
O95503 (/IPI)
O95931 (/IPI)
O95931 (/IPI)
O95931 (/IPI)
O95931 (/IPI)
(10 more) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
5 | F8VQB8 (/IPI) H3BLN6 (/IPI) Q6TKP2 (/IPI) Q6TLW0 (/IPI) Q6TLW1 (/IPI) |
|
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
4 | O55187 (/IDA) Q8VDS3 (/IDA) Q9DBY5 (/IDA) Q9QXV1 (/IDA) |
|
SUMO transferase activity GO:0019789
Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
|
4 | O00257 (/EXP) O00257 (/EXP) O00257 (/EXP) O55187 (/EXP) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
4 | O00257 (/IDA) O00257 (/IDA) O00257 (/IDA) O55187 (/IDA) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
4 | O55187 (/IDA) P30658 (/IDA) Q8VDS3 (/IDA) Q9HC52 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | O55187 (/IDA) P30658 (/IDA) Q8VDS3 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
3 | O00257 (/TAS) O00257 (/TAS) O00257 (/TAS) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
3 | O00257 (/IPI) O00257 (/IPI) O00257 (/IPI) |
|
SUMO transferase activity GO:0019789
Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
|
1 | O55187 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | O55187 (/ISO) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
1 | O55187 (/ISO) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q9QXV1 (/ISO) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | O55187 (/IDA) |
|
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
|
1 | O55187 (/IPI) |
|
Ubiquitin-protein transferase activator activity GO:0097027
Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.
|
1 | Q9QXV1 (/IDA) |
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
17 |
O00257 (/IMP)
O00257 (/IMP)
O00257 (/IMP)
O55187 (/IMP)
O95503 (/IMP)
O95503 (/IMP)
O95931 (/IMP)
O95931 (/IMP)
O95931 (/IMP)
O95931 (/IMP)
(7 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | O55187 (/ISO) P30658 (/ISO) Q8VDS3 (/ISO) Q9DBY5 (/ISO) Q9QXV1 (/ISO) |
|
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
|
3 | A8KC45 (/IMP) Q502N4 (/IMP) X1WBY5 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | O00257 (/TAS) O00257 (/TAS) O00257 (/TAS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O00257 (/IDA) O00257 (/IDA) O00257 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O55187 (/IDA) P30658 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | O55187 (/IGI) |
|
Developmental process involved in reproduction GO:0003006
A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
|
1 | P60889 (/IEP) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q9QXV1 (/ISS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q4FZS1 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q9QXV1 (/ISO) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
1 | Q9QXV1 (/IDA) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
1 | O55187 (/IMP) |
|
Positive regulation of collagen biosynthetic process GO:0032967
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
|
1 | Q4FZS1 (/IMP) |
|
Positive regulation of collagen biosynthetic process GO:0032967
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
|
1 | Q9QXV1 (/ISO) |
|
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
1 | P60889 (/IMP) |
|
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
1 | Q8VDS3 (/ISO) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P60889 (/IEP) |
|
Development of primary sexual characteristics GO:0045137
The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.
|
1 | Q14781 (/IMP) |
|
Development of primary sexual characteristics GO:0045137
The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.
|
1 | P30658 (/ISO) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
1 | Q4FZS1 (/IMP) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
1 | Q9QXV1 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O55187 (/ISO) |
|
Sebaceous gland development GO:0048733
The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure.
|
1 | Q8VDS3 (/IMP) |
|
Epithelial cell proliferation GO:0050673
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
|
1 | Q05BI5 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | Q4FZS1 (/IEP) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
27 |
F8VQB8 (/IDA)
H3BLN6 (/IDA)
O00257 (/IDA)
O00257 (/IDA)
O00257 (/IDA)
O55187 (/IDA)
O95503 (/IDA)
O95503 (/IDA)
O95931 (/IDA)
O95931 (/IDA)
(17 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
26 |
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A0S2Z5B2 (/IDA)
(16 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
23 |
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
A0A024R1Q2 (/IDA)
F8VQB8 (/IDA)
(13 more) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
18 |
O00257 (/IDA)
O00257 (/IDA)
O00257 (/IDA)
O95503 (/IDA)
O95503 (/IDA)
O95931 (/IDA)
O95931 (/IDA)
O95931 (/IDA)
O95931 (/IDA)
O95931 (/IDA)
(8 more) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
13 |
O55187 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
O95931 (/ISS)
(3 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
10 | O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) O95931 (/IDA) Q9HC52 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
8 | O00257 (/TAS) O00257 (/TAS) O00257 (/TAS) O55187 (/TAS) O95503 (/TAS) O95503 (/TAS) Q14781 (/TAS) Q9HC52 (/TAS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
7 | A0A0S2Z5B2 (/IDA) A0A0S2Z5B2 (/IDA) A0A0S2Z5B2 (/IDA) O00257 (/IDA) O00257 (/IDA) O00257 (/IDA) O55187 (/IDA) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
6 | O00257 (/IDA) O00257 (/IDA) O00257 (/IDA) Q14781 (/IDA) Q8VDS3 (/IDA) Q9HC52 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O55187 (/ISO) P30658 (/ISO) Q8VDS3 (/ISO) Q9DBY5 (/ISO) Q9QXV1 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | F8VQB8 (/IDA) H3BLN6 (/IDA) Q6TKP2 (/IDA) Q6TLW0 (/IDA) Q6TLW1 (/IDA) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
5 | F8VQB8 (/IDA) H3BLN6 (/IDA) Q6TKP2 (/IDA) Q6TLW0 (/IDA) Q6TLW1 (/IDA) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
5 | F8VQB8 (/IDA) H3BLN6 (/IDA) Q6TKP2 (/IDA) Q6TLW0 (/IDA) Q6TLW1 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
5 | F8VQB8 (/IDA) H3BLN6 (/IDA) Q6TKP2 (/IDA) Q6TLW0 (/IDA) Q6TLW1 (/IDA) |
|
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
5 | F8VQB8 (/IDA) H3BLN6 (/IDA) Q6TKP2 (/IDA) Q6TLW0 (/IDA) Q6TLW1 (/IDA) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
5 | O55187 (/ISO) P30658 (/ISO) Q8VDS3 (/ISO) Q9DBY5 (/ISO) Q9QXV1 (/ISO) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
5 | F8VQB8 (/IDA) H3BLN6 (/IDA) Q6TKP2 (/IDA) Q6TLW0 (/IDA) Q6TLW1 (/IDA) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
4 | P30658 (/IDA) Q8VDS3 (/IDA) Q9DBY5 (/IDA) Q9QXV1 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | O55187 (/ISO) P30658 (/ISO) Q8VDS3 (/ISO) Q9QXV1 (/ISO) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
4 | O55187 (/ISS) P60889 (/ISS) Q8VDS3 (/ISS) Q9DBY5 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O00257 (/TAS) O00257 (/TAS) O00257 (/TAS) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
3 | O55187 (/ISO) P30658 (/ISO) Q9QXV1 (/ISO) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | Q8VDS3 (/ISO) Q9QXV1 (/ISO) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
1 | Q9QXV1 (/IDA) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
1 | P30658 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9QXV1 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8VDS3 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | O55187 (/ISO) |
