The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Histone-lysine N-methyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
29 O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS)
(19 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI)
(5 more)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
15 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(5 more)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
15 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(5 more)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
15 Q2NL30 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS)
(5 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
14 O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS)
(4 more)
S-adenosylmethionine-dependent methyltransferase activity GO:0008757
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
14 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(4 more)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
14 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(4 more)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
14 O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP) O43463 (/EXP)
(4 more)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
14 O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI) O43463 (/IPI)
(4 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 O54864 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 O54864 (/IDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 O54864 (/IDA)
Protein methyltransferase activity GO:0008276
Catalysis of the transfer of a methyl group (CH3-) to a protein.
1 O54864 (/TAS)
S-adenosylmethionine-dependent methyltransferase activity GO:0008757
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
1 O54864 (/ISO)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 O54864 (/IGI)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 O54864 (/ISO)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
1 O54864 (/ISO)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 O54864 (/ISO)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 O54864 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone H3-K9 dimethylation GO:0036123
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.
29 O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS)
(19 more)
Histone H3-K9 trimethylation GO:0036124
The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.
29 O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS)
(19 more)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
29 O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS)
(19 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
29 O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS) O43463 (/ISS)
(19 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
14 O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP) O43463 (/IMP)
(4 more)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
14 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(4 more)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
14 O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS)
(4 more)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
14 O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS)
(4 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
14 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(4 more)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
14 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(4 more)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
3 A0A2R8QCU6 (/IMP) A4FUM2 (/IMP) B0S6M0 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O54864 (/ISO)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
1 O54864 (/ISO)
Blastocyst hatching GO:0001835
The hatching of the cellular blastocyst from the zona pellucida.
1 O54864 (/IMP)
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
1 O54864 (/IMP)
DNA packaging GO:0006323
Any process in which DNA and associated proteins are formed into a compact, orderly structure.
1 O54864 (/TAS)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 O54864 (/TAS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 O54864 (/ISO)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 O54864 (/IGI)
Regulation of bone mineralization GO:0030500
Any process that modulates the frequency, rate or extent of bone mineralization.
1 O54864 (/IGI)
Histone lysine methylation GO:0034968
The modification of a histone by addition of one or more methyl groups to a lysine residue.
1 O54864 (/IGI)
Histone H3-K9 dimethylation GO:0036123
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.
1 O54864 (/IMP)
Histone H3-K9 trimethylation GO:0036124
The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.
1 O54864 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 O54864 (/IGI)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
1 O54864 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O54864 (/IMP)
Histone H3-K9 methylation GO:0051567
The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.
1 O54864 (/IDA)
Histone H3-K9 methylation GO:0051567
The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.
1 O54864 (/IGI)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O54864 (/ISO)
Positive regulation of histone H3-K9 trimethylation GO:1900114
Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation.
1 O54864 (/IMP)
Regulation of cellular senescence GO:2000772
Any process that modulates the frequency, rate or extent of cellular senescence.
1 O54864 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
15 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(5 more)
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
15 Q2NL30 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 Q2NL30 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS) Q5RB81 (/ISS)
(5 more)
Chromatin silencing complex GO:0005677
Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.
15 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(5 more)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
14 O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
14 O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS) O43463 (/TAS)
(4 more)
RDNA heterochromatin GO:0033553
A region of heterochromatin located at the rDNA repeats in a chromosome.
14 O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA) O43463 (/IDA)
(4 more)
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
1 O54864 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O54864 (/ISO)
Chromatin silencing complex GO:0005677
Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.
1 O54864 (/ISO)
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
1 O54864 (/TAS)
RDNA heterochromatin GO:0033553
A region of heterochromatin located at the rDNA repeats in a chromosome.
1 O54864 (/ISO)
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