The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Stromal cell-derived factor 1 precursor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
8 E2IFI5 (/IMP) P48061 (/IMP) P48061 (/IMP) P48061 (/IMP) Q6T7B9 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
5 P40224 (/IDA) P48061 (/IDA) P48061 (/IDA) P48061 (/IDA) Q8UUJ9 (/IDA)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
5 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS) Q80YV8 (/TAS) Q9QZD1 (/TAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
4 O62657 (/ISS) P40224 (/ISS) Q5EBF6 (/ISS) Q8UUJ9 (/ISS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P48061 (/IPI) P48061 (/IPI) P48061 (/IPI)
Chemokine receptor binding GO:0042379
Interacting selectively and non-covalently with any chemokine receptor.
3 P48061 (/IMP) P48061 (/IMP) P48061 (/IMP)
CXCR chemokine receptor binding GO:0045236
Interacting selectively and non-covalently with a chemokine receptor in the CXCR family.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
2 Q6V9B5 (/IDA) Q8AV10 (/IDA)
Chemokine receptor binding GO:0042379
Interacting selectively and non-covalently with any chemokine receptor.
2 O62657 (/ISS) P40224 (/ISS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P40224 (/ISO)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
1 P40224 (/ISO)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
1 Q5EBF6 (/ISS)
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
1 Q8AV10 (/IMP)
Chemokine receptor binding GO:0042379
Interacting selectively and non-covalently with any chemokine receptor.
1 P40224 (/ISO)
CXCR chemokine receptor binding GO:0045236
Interacting selectively and non-covalently with a chemokine receptor in the CXCR family.
1 P40224 (/ISO)

There are 132 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
8 E2IFI5 (/IMP) Q6T7B9 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP) Q80YV8 (/IMP) Q8AV10 (/IMP) Q9QZD1 (/IMP)
Cell communication GO:0007154
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
5 E2IFI5 (/IMP) Q6T7B9 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP)
Muscle cell migration GO:0014812
The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.
5 E2IFI5 (/IMP) Q6T7B9 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP)
Positive regulation of muscle tissue development GO:1901863
Any process that activates or increases the frequency, rate or extent of muscle tissue development.
5 E2IFI5 (/IMP) Q6T7B9 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP) Q6T7C0 (/IMP)
Integrin activation GO:0033622
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
4 O62657 (/ISS) P40224 (/ISS) Q5EBF6 (/ISS) Q8UUJ9 (/ISS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
4 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA) Q8UUJ9 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Integrin activation GO:0033622
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Chemokine (C-X-C motif) ligand 12 signaling pathway GO:0038146
A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P48061 (/IMP) P48061 (/IMP) P48061 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Chemokine-mediated signaling pathway GO:0070098
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Positive regulation of calcium ion import GO:0090280
Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Negative regulation of leukocyte tethering or rolling GO:1903237
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
3 P48061 (/IMP) P48061 (/IMP) P48061 (/IMP)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
3 P48061 (/IDA) P48061 (/IDA) P48061 (/IDA)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 Q6V9B5 (/IMP) Q8AV10 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q80YV8 (/TAS) Q9QZD1 (/TAS)
Trigeminal sensory nucleus development GO:0021730
The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure.
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Telencephalon cell migration GO:0022029
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Positive regulation of dopamine secretion GO:0033603
Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
2 Q6V9B5 (/IMP) Q8AV10 (/IMP)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Detection of mechanical stimulus involved in sensory perception of pain GO:0050966
The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.
2 Q80YV8 (/IMP) Q9QZD1 (/IMP)
Regulation of intracellular pH GO:0051453
Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Lymphoid lineage cell migration into thymus GO:0097535
The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process.
2 Q6V9B5 (/IGI) Q8AV10 (/IGI)
Response to ultrasound GO:1990478
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus.
2 Q80YV8 (/IEP) Q9QZD1 (/IEP)
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
1 P40224 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q6V9B5 (/IMP)
Ameboidal-type cell migration GO:0001667
Cell migration that is accomplished by extension and retraction of a pseudopodium.
1 P40224 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 P40224 (/ISO)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P40224 (/ISO)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
1 Q8AV10 (/IMP)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 Q6V9B5 (/IMP)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 Q6V9B5 (/IGI)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 Q6V9B5 (/IMP)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q8AV10 (/IGI)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q8AV10 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q8UUJ9 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q5EBF6 (/ISS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 Q8UUJ9 (/IDA)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 P40224 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q8AV10 (/IGI)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q8AV10 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P40224 (/IDA)
Mesoderm migration involved in gastrulation GO:0007509
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
1 Q8UUJ9 (/IMP)
Mesoderm migration involved in gastrulation GO:0007509
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
1 Q5EBF6 (/ISS)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 P40224 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P40224 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8AV10 (/IDA)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 P40224 (/ISO)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
1 P40224 (/IDA)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
1 Q8AV10 (/IMP)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q8AV10 (/IMP)
Telencephalon cell migration GO:0022029
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.
1 P40224 (/ISO)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q6V9B5 (/IMP)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
1 Q8AV10 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 P40224 (/IDA)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 P40224 (/IGI)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P40224 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P40224 (/ISO)
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
1 Q8AV10 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q8AV10 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P40224 (/ISO)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
1 Q8AV10 (/IDA)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
1 Q8AV10 (/IMP)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
1 Q8AV10 (/IDA)
Positive regulation of dopamine secretion GO:0033603
Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine.
1 P40224 (/ISO)
Integrin activation GO:0033622
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
1 P40224 (/ISO)
Hematopoietic stem cell migration GO:0035701
The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
1 Q8AV10 (/IGI)
Chemokine (C-X-C motif) ligand 12 signaling pathway GO:0038146
A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P40224 (/ISO)
T cell proliferation GO:0042098
The expansion of a T cell population by cell division. Follows T cell activation.
1 P40224 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 P40224 (/ISO)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 P40224 (/ISO)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
1 Q8AV10 (/IDA)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
1 P40224 (/ISO)
Posterior lateral line neuromast primordium migration GO:0048920
The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.
1 Q8AV10 (/IGI)
Posterior lateral line neuromast primordium migration GO:0048920
The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.
1 Q8AV10 (/IMP)
Induction of positive chemotaxis GO:0050930
Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
1 P40224 (/IDA)
Induction of positive chemotaxis GO:0050930
Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
1 Q6V9B5 (/IGI)
Induction of positive chemotaxis GO:0050930
Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
1 Q8AV10 (/IMP)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
1 P40224 (/ISO)
Detection of mechanical stimulus involved in sensory perception of pain GO:0050966
The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.
1 P40224 (/ISO)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P40224 (/ISO)
Striated muscle cell development GO:0055002
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
1 Q8AV10 (/IMP)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 P40224 (/ISO)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q5EBF6 (/ISS)
Chemokine-mediated signaling pathway GO:0070098
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P40224 (/ISO)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
1 P40224 (/IDA)
Regulation of neutrophil chemotaxis GO:0090022
Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 Q8AV10 (/IMP)
Negative regulation of neutrophil chemotaxis GO:0090024
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 Q8AV10 (/IGI)
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
1 P40224 (/ISO)
Positive regulation of calcium ion import GO:0090280
Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
1 P40224 (/IDA)
Lymphoid lineage cell migration into thymus GO:0097535
The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process.
1 Q6V9B5 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P40224 (/IDA)
Regulation of inflammatory response to wounding GO:0106014
Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.
1 Q8AV10 (/IMP)
Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
1 P40224 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
1 P40224 (/ISO)
Negative regulation of leukocyte tethering or rolling GO:1903237
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.
1 P40224 (/ISO)
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
1 P40224 (/ISO)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
1 P40224 (/ISO)
Negative regulation of hematopoietic stem cell migration GO:2000472
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration.
1 Q8AV10 (/IGI)
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
1 P40224 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P48061 (/TAS) P48061 (/TAS) P48061 (/TAS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
3 P48061 (/HDA) P48061 (/HDA) P48061 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P48061 (/HDA) P48061 (/HDA) P48061 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q80YV8 (/IDA) Q9QZD1 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P40224 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P40224 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P40224 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P40224 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P40224 (/IDA)
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