The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Nucleic acid-binding proteins
".
FunFam 292: Probable ATP-dependent DNA ligase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
|
4 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) Q9I1X7 (/IDA) |
|
DNA ligase (ATP) activity GO:0003910
Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
|
4 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) Q9I1X7 (/IDA) |
|
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
DNA primase activity GO:0003896
Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
DNA ligase activity GO:0003909
Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Single-stranded DNA 3'-5' exodeoxyribonuclease activity GO:0008310
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Ribonucleotide binding GO:0032553
Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
|
1 | Q9I1X7 (/IDA) |
|
Nucleotidyltransferase activity GO:0016779
Catalysis of the transfer of a nucleotidyl group to a reactant.
|
1 | Q9I1X7 (/IDA) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA ligation GO:0006266
The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
DNA replication, synthesis of RNA primer GO:0006269
The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
3 | P9WNV3 (/IDA) P9WNV3 (/IDA) P9WNV3 (/IDA) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
1 | A0R3R7 (/IMP) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
1 | A0R3R7 (/IPI) |
|
DNA biosynthetic process GO:0071897
The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
|
1 | Q9I1X7 (/IDA) |
|
RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503
The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.
|
1 | Q9I1X7 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P9WNV3 (/HDA) P9WNV3 (/HDA) P9WNV3 (/HDA) |
