The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 25: 40S ribosomal protein S28

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
140 P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI) P62857 (/IPI)
(130 more)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
84 P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS)
(74 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
70 P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA)
(60 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
70 P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS)
(60 more)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
32 P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA)
(22 more)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
14 Q9VAB9 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS) Q9W334 (/ISS)
(4 more)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
5 P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 P34789 (/IDA) P34789 (/IDA)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
409 O61590 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS)
(399 more)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
280 P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS)
(270 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
80 P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO)
(70 more)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
75 P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO)
(65 more)
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
70 P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS)
(60 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
70 P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA)
(60 more)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
70 P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP)
(60 more)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
70 P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO)
(60 more)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
70 P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC) P62857 (/IC)
(60 more)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
70 P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS)
(60 more)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
70 P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS)
(60 more)
SRP-dependent cotranslational protein targeting to membrane GO:0006614
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
70 P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS)
(60 more)
Viral transcription GO:0019083
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.
70 P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS)
(60 more)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
70 P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP)
(60 more)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
70 P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP) P62857 (/IMP)
(60 more)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
70 P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO)
(60 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
35 P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC) P0C0X0 (/IC)
(25 more)
RRNA export from nucleus GO:0006407
The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.
21 P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI) P0C0X0 (/IGI)
(11 more)
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
21 P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP) P0C0X0 (/IMP)
(11 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
14 Q9VAB9 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS) Q9W334 (/TAS)
(4 more)
Ribosomal small subunit assembly GO:0000028
The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
5 P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP)
Ribosomal small subunit export from nucleus GO:0000056
The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
5 P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP)
Cleavage involved in rRNA processing GO:0000469
Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.
5 P0CT80 (/IDA) P0CT80 (/IDA) P0CT80 (/IDA) P0CT80 (/IDA) P0CT80 (/IDA)
Maturation of SSU-rRNA GO:0030490
Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
5 P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP) P0CT80 (/IMP)
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
1 Q9VAB9 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
409 O61590 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS)
(399 more)
Cytoplasmic side of rough endoplasmic reticulum membrane GO:0098556
The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.
409 O61590 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS) P62857 (/ISS)
(399 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
283 O61590 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS) P62858 (/ISS)
(273 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
242 P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA) P0C0X0 (/IDA)
(232 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
84 P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS) P62859 (/TAS)
(74 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
80 P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT79 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO) P0CT80 (/ISO)
(70 more)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
72 P34789 (/IDA) P34789 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA) P62857 (/IDA)
(62 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
70 P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS)
(60 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
70 P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS) P62857 (/TAS)
(60 more)
Small ribosomal subunit GO:0015935
The smaller of the two subunits of a ribosome.
70 P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA)
(60 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
70 P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA)
(60 more)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
70 P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO) P62858 (/ISO)
(60 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
70 P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA) P62857 (/HDA)
(60 more)
Cytoplasmic side of rough endoplasmic reticulum membrane GO:0098556
The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.
70 Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA) Q6QAT1 (/IDA)
(60 more)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
11 P34789 (/IDA) P34789 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P0CT79 (/HDA) P0CT79 (/HDA) P0CT79 (/HDA) P0CT79 (/HDA) P0CT79 (/HDA) P0CT80 (/HDA) P0CT80 (/HDA) P0CT80 (/HDA) P0CT80 (/HDA) P0CT80 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA) Q9SR73 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
5 P0CT80 (/IDA) P0CT80 (/IDA) P0CT80 (/IDA) P0CT80 (/IDA) P0CT80 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...