View in Gene3D

CATH Superfamily 2.40.50.140

Nucleic acid-binding proteins

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 24: Lysine--tRNA ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysine-tRNA ligase activity GO:0004824
Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
 143 P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA)
(133 more)
Lysine-tRNA ligase activity GO:0004824
Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
 143 P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI)
(133 more)
Ligase activity GO:0016874
Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
 143 P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA)
(133 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 83 P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI) P0A8N3 (/IPI)
(73 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
 63 P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA)
(53 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
 63 P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA)
(53 more)
Lysine-tRNA ligase activity GO:0004824
Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
 4 Q9KU60 (/ISS) Q9KU60 (/ISS) Q9KU60 (/ISS) Q9KU60 (/ISS)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TRNA aminoacylation for protein translation GO:0006418
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
 143 P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI)
(133 more)
Lysyl-tRNA aminoacylation GO:0006430
The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.
 143 P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI) P0A8N3 (/IGI)
(133 more)
Lysyl-tRNA aminoacylation GO:0006430
The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.
 63 P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA) P0A8N5 (/IDA)
(53 more)
Lysyl-tRNA aminoacylation GO:0006430
The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.
 4 Q9KU60 (/ISS) Q9KU60 (/ISS) Q9KU60 (/ISS) Q9KU60 (/ISS)
Plant ovule development GO:0048481
The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed.
 1 Q9LJE2 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 143 P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA)
(133 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 143 P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA) P0A8N3 (/IDA)
(133 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 143 P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA) P0A8N3 (/HDA)
(133 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
 1 Q9LJE2 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
 1 Q9LJE2 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...