The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135: Exosome complex component CSL4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 Q9DAA6 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI) Q9Y3B2 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
9 Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
9 Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
9 Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
1 Q9DAA6 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
9 Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA)
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
9 Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS) Q9Y3B2 (/NAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
9 Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA) Q9Y3B2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS) Q9Y3B2 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
5 B8A4H5 (/ISS) Q5E9E9 (/ISS) Q5E9E9 (/ISS) Q5E9E9 (/ISS) Q9DAA6 (/ISS)
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
1 Q9DAA6 (/ISO)
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
1 Q9DAA6 (/ISS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9DAA6 (/ISO)
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