View in Gene3D

CATH Superfamily 2.40.50.1010

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA(Ile)(2)-agmatinylcytidine synthase. [EC: 6.3.4.22]
ATP + agmatine + (tRNA(Ile)(2))-cytidine(34) + H(2)O = (tRNA(Ile)(2))-2- agmatinylcytidine(34) + AMP + 2 phosphate.
  • The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNA(Ile)(2) at the oxo group in position 2 of cytidine(34).
  • This modification is crucial for accurate decoding of the genetic code.
  • In bacteria EC 6.3.4.19, catalyzes the modification of (tRNA(Ile)(2))-cytidine(34) to (tRNA(Ile)(2))-lysidine(34).
 9 A0A075WGX8 A0A075WGX8 A0A075WGX8 A0A101DD05 A0A101DD05 A0A101DD05 O28025 O28025 O28025