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CATH Superfamily 2.40.50.100

RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Acetyl-CoA carboxylase biotin carboxyl carrier pro...

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Biotin carboxylase. [EC: 6.3.4.14]
ATP + [biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]- carboxybiotin-N(6)-L-lysine.
  • This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15.
  • In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria).
  • Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyzes the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2).
 73 A0A045I6A4 A0A045I6A4 A0A045I6A4 A0A045I6A4 A0A045I6A4 A0A045I6A4 A0A045I6A4 A0A045I6A4 A0A0H3MCS0 A0A0H3MCS0
(63 more...)
Pyruvate carboxylase. [EC: 6.4.1.1]
ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.
  • The animal enzyme requires acetyl-CoA.
 27 A0A024R5C5 A0A024R5C5 A0A164SJG0 A0A164SJG0 A0A164SJG0 A0A164SJG0 A0A1B2B3P8 A0A1B2B3P8 A0A1B2B3P8 A0A1B2B3P8
(17 more...)
Methylcrotonoyl-CoA carboxylase. [EC: 6.4.1.4]
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA.
    		 9 A0A0S2Z693 A0A0S2Z693 Q42523 Q42777 Q54KE6 Q5I0C3 Q96RQ3 Q96RQ3 Q99MR8
    Urea carboxylase. [EC: 6.3.4.6]
    ATP + urea + HCO(3)(-) = ADP + phosphate + urea-1-carboxylate.
    • The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 3.5.1.54, thus bringing about the hydrolysis of urea to CO(2) and NH(3).
    • The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates.
    • Formerly EC 3.5.1.45.
    		 4 C7GKH0 C7GKH0 P32528 P32528
    Allophanate hydrolase. [EC: 3.5.1.54]
    Urea-1-carboxylate + H(2)O = 2 CO(2) + 2 NH(3).
    • Along with EC 3.5.2.15 and EC 3.5.1.84, forms part of the cyanuric- acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine (2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5- triazine), in bacteria.
    • The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 6.3.4.6, thus bringing about the hydrolysis of urea to CO(2) and NH(3) in the presence of ATP and bicarbonate.
    • The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate.
    		 4 C7GKH0 C7GKH0 P32528 P32528
    Propionyl-CoA carboxylase. [EC: 6.4.1.3]
    ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl- CoA.
    • Also carboxylates butanoyl-CoA and catalyzes transcarboxylation.
    		 1 I3R7G3
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