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CATH Superfamily 2.40.40.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: NADH-quinone oxidoreductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 13 P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI) P33602 (/IPI)
(3 more)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
 13 P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA)
(3 more)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
 13 P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA)
(3 more)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
 1 Q608Y2 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
 13 P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP)
(3 more)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
 1 Q608Y2 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 13 P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA)
(3 more)
NADH dehydrogenase complex GO:0030964
An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.
 13 P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA)
(3 more)
Plasma membrane respiratory chain complex I GO:0045272
A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.
 13 P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA) P33602 (/IDA)
(3 more)
Plasma membrane respiratory chain complex I GO:0045272
A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.
 13 P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP) P33602 (/IMP)
(3 more)