The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Translation factors
".
FunFam 11: Eukaryotic translation initiation factor 2 subunit...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
29 |
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P32481 (/IPI)
P41091 (/IPI)
(19 more) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
18 |
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
(8 more) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
12 |
Q24208 (/ISS)
Q24208 (/ISS)
Q24208 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2VIR0 (/ISS)
Q2VIR2 (/ISS)
(2 more) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
9 | P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) |
|
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
|
9 | Q2KHU8 (/ISS) Q2KHU8 (/ISS) Q2KHU8 (/ISS) Q2KHU8 (/ISS) Q2KHU8 (/ISS) Q2VIR0 (/ISS) Q2VIR2 (/ISS) Q9Z0N1 (/ISS) Q9Z0N1 (/ISS) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
9 | P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
6 | P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) |
|
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
6 | P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) |
|
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
|
6 | P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) |
|
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
|
6 | P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
6 | P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
2 | Q9Z0N1 (/ISO) Q9Z0N1 (/ISO) |
|
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
|
2 | Q9Z0N1 (/ISO) Q9Z0N1 (/ISO) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
1 | Q09130 (/IGI) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
27 |
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2KHU8 (/ISS)
Q2VIR0 (/ISS)
Q2VIR2 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
Q8ILY9 (/ISS)
(17 more) |
|
Formation of translation preinitiation complex GO:0001731
The joining of the small ribosomal subunit, ternary complex, and mRNA.
|
9 | P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
9 | P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) |
|
Positive regulation of translational fidelity GO:0045903
Any process that increases the ability of the translational apparatus to interpret the genetic code.
|
9 | P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
6 | P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
6 | P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) |
|
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
6 | P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) |
|
Formation of translation preinitiation complex GO:0001731
The joining of the small ribosomal subunit, ternary complex, and mRNA.
|
3 | Q24208 (/ISS) Q24208 (/ISS) Q24208 (/ISS) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
2 | Q9Z0N1 (/ISO) Q9Z0N1 (/ISO) |
|
Formation of translation preinitiation complex GO:0001731
The joining of the small ribosomal subunit, ternary complex, and mRNA.
|
1 | Q09130 (/IGI) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
|
45 |
C9WPN6 (/ISS)
F1QGW6 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
P81795 (/ISS)
(35 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) P32481 (/HDA) Q09130 (/HDA) |
|
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
|
9 | P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) P32481 (/IMP) |
|
Eukaryotic 43S preinitiation complex GO:0016282
A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
|
9 | P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) |
|
Eukaryotic 48S preinitiation complex GO:0033290
A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
|
9 | P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) |
|
Multi-eIF complex GO:0043614
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
|
9 | P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) P32481 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) P41091 (/TAS) |
|
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
|
6 | P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) P41091 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
6 | P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) P41091 (/HDA) |
|
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
|
3 | Q09130 (/ISO) Q9Z0N1 (/ISO) Q9Z0N1 (/ISO) |
|
Eukaryotic 43S preinitiation complex GO:0016282
A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
|
3 | Q24208 (/ISS) Q24208 (/ISS) Q24208 (/ISS) |
|
Multi-eIF complex GO:0043614
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
|
3 | Q24208 (/ISS) Q24208 (/ISS) Q24208 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9Z0N1 (/ISO) Q9Z0N1 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O64490 (/IDA) O64490 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q09130 (/HDA) |
