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CATH Superfamily 2.40.20.10

Plasminogen Kringle 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Plasminogen Kringle 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Urokinase-type plasminogen activator

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
T-plasminogen activator. [EC: 3.4.21.68]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • From a wide variety of mammalian tissues, especially endothelial cells.
  • Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin.
  • Activity is considerably enhanced by fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
 18 A0A480NSF2 A0A480NSF2 A0A480NSF2 A0A480NSF2 P00750 P00750 P11214 P11214 P19637 P19637
(8 more...)
U-plasminogen activator. [EC: 3.4.21.73]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • Formed from the inactive precursor by action of plasmin or plasma kallikrein.
  • Differs in structure from EC 3.4.21.68, and does not bind to fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
 13 A0A024QZM9 A0A024QZM9 P00749 P00749 P04185 P06869 P06869 P16227 P29598 Q05589
(3 more...)