The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Oxysterol-binding protein homolog 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxysterol binding GO:0008142
Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.
5 P35843 (/ISS) P35843 (/ISS) P35844 (/ISS) P35844 (/ISS) P35844 (/ISS)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
5 P35843 (/IDA) P35843 (/IDA) P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Sterol transfer activity GO:0120015
Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
5 P35843 (/IDA) P35843 (/IDA) P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
3 P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Oxysterol binding GO:0008142
Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.
3 P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
3 P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Sterol transporter activity GO:0015248
Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Sterol transfer activity GO:0120015
Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
3 P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Oxysterol binding GO:0008142
Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.
2 P35843 (/IDA) P35843 (/IDA)
Oxysterol binding GO:0008142
Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.
2 O43021 (/ISO) O74178 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
5 P35843 (/IGI) P35843 (/IGI) P35844 (/IGI) P35844 (/IGI) P35844 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
5 P35843 (/IGI) P35843 (/IGI) P35844 (/IGI) P35844 (/IGI) P35844 (/IGI)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
5 P35843 (/IDA) P35843 (/IDA) P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
5 P35843 (/IGI) P35843 (/IGI) P35844 (/IGI) P35844 (/IGI) P35844 (/IGI)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
5 P35843 (/IMP) P35843 (/IMP) P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Maintenance of cell polarity GO:0030011
The maintenance of established anisotropic intracellular organization or cell growth patterns.
5 P35843 (/IGI) P35843 (/IGI) P35844 (/IGI) P35844 (/IGI) P35844 (/IGI)
Piecemeal microautophagy of the nucleus GO:0034727
Degradation of a cell nucleus by lysosomal microautophagy.
5 P35843 (/IGI) P35843 (/IGI) P35844 (/IGI) P35844 (/IGI) P35844 (/IGI)
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
3 P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Post-Golgi vesicle-mediated transport GO:0006892
The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
3 P35844 (/IGI) P35844 (/IGI) P35844 (/IGI)
Positive regulation of phosphatase activity GO:0010922
Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
ER to Golgi ceramide transport GO:0035621
The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.
3 P35844 (/IMP) P35844 (/IMP) P35844 (/IMP)
Intermembrane sterol transfer GO:0120011
The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).
2 O43021 (/ISO) O74178 (/ISO)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 O43021 (/NAS)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P35844 (/HDA) P35844 (/HDA) P35844 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P35844 (/HDA) P35844 (/HDA) P35844 (/HDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
3 P35844 (/IDA) P35844 (/IDA) P35844 (/IDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
2 P35843 (/HDA) P35843 (/HDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
2 P35843 (/HDA) P35843 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O43021 (/HDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 O74178 (/HDA)
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