The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Butyryl-CoA Dehydrogenase, subunit A, domain 2
".
FunFam 2: Acyl-CoA dehydrogenase fadE12
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor GO:0052890
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin.
|
74 |
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
(64 more) |
Citronellyl-CoA dehydrogenase activity GO:0034824
Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+.
|
16 |
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9I3H8 (/IDA)
Q9I3H8 (/IDA)
(6 more) |
Acyl-CoA dehydrogenase activity GO:0003995
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
|
12 |
P9WQG3 (/IDA)
P9WQG3 (/IDA)
P9WQG3 (/IDA)
P9WQG3 (/IDA)
P9WQG3 (/IDA)
P9WQG3 (/IDA)
P9WQG3 (/IDA)
P9WQG3 (/IDA)
Q4KCY6 (/IDA)
Q4KCY6 (/IDA)
(2 more) |
Acyl-CoA dehydrogenase activity GO:0003995
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
|
2 | Q95S48 (/ISS) Q9VGC2 (/ISS) |
Acyl-CoA dehydrogenase activity GO:0003995
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
|
2 | Q6JQN1 (/TAS) Q709F0 (/TAS) |
Long-chain-acyl-CoA dehydrogenase activity GO:0004466
Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
|
2 | P15650 (/IDA) Q709F0 (/IDA) |
Long-chain-acyl-CoA dehydrogenase activity GO:0004466
Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
|
2 | P51174 (/ISO) Q80XL6 (/ISO) |
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
1 | P15650 (/IDA) |
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
1 | P51174 (/ISO) |
Long-chain-acyl-CoA dehydrogenase activity GO:0004466
Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
|
1 | P51174 (/IMP) |
Long-chain-acyl-CoA dehydrogenase activity GO:0004466
Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
|
1 | P28330 (/ISS) |
Long-chain-acyl-CoA dehydrogenase activity GO:0004466
Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
|
1 | P28330 (/TAS) |
Palmitoyl-CoA oxidase activity GO:0016401
Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide.
|
1 | P51174 (/IMP) |
Palmitoyl-CoA oxidase activity GO:0016401
Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide.
|
1 | P28330 (/ISS) |
Very-long-chain-acyl-CoA dehydrogenase activity GO:0017099
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.
|
1 | Q709F0 (/IDA) |
Very-long-chain-acyl-CoA dehydrogenase activity GO:0017099
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.
|
1 | Q80XL6 (/ISO) |
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | P15650 (/IDA) |
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | P51174 (/ISO) |
Medium-chain-acyl-CoA dehydrogenase activity GO:0070991
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
|
1 | Q709F0 (/IDA) |
Medium-chain-acyl-CoA dehydrogenase activity GO:0070991
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
|
1 | Q80XL6 (/ISO) |
There are 35 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
1-butanol biosynthetic process GO:0071271
The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O.
|
74 |
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
P0A9U8 (/IMP)
(64 more) |
Terpene catabolic process GO:0046247
The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units.
|
16 |
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9HZV8 (/IDA)
Q9I3H8 (/IDA)
Q9I3H8 (/IDA)
(6 more) |
Terpene catabolic process GO:0046247
The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units.
|
8 | Q9HZV8 (/IMP) Q9HZV8 (/IMP) Q9HZV8 (/IMP) Q9HZV8 (/IMP) Q9HZV8 (/IMP) Q9HZV8 (/IMP) Q9HZV8 (/IMP) Q9HZV8 (/IMP) |
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
8 | P9WQG3 (/IDA) P9WQG3 (/IDA) P9WQG3 (/IDA) P9WQG3 (/IDA) P9WQG3 (/IDA) P9WQG3 (/IDA) P9WQG3 (/IDA) P9WQG3 (/IDA) |
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
3 | P28330 (/TAS) Q6JQN1 (/TAS) Q709F0 (/TAS) |
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
2 | Q95S48 (/ISS) Q9VGC2 (/ISS) |
Fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539
A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
2 | P15650 (/IDA) Q709F0 (/IDA) |
Fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539
A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
2 | P51174 (/ISO) Q80XL6 (/ISO) |
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | P15650 (/ISS) P28330 (/ISS) |
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
|
1 | P51174 (/IMP) |
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
|
1 | P28330 (/ISS) |
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | P51174 (/IMP) |
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
1 | P51174 (/IMP) |
Carnitine metabolic process, CoA-linked GO:0019254
The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.
|
1 | P51174 (/IMP) |
Carnitine metabolic process, CoA-linked GO:0019254
The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.
|
1 | P28330 (/ISS) |
Fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539
A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | P51174 (/IMP) |
Fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539
A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | P28330 (/ISS) |
Carnitine catabolic process GO:0042413
The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
|
1 | P51174 (/IMP) |
Carnitine catabolic process GO:0042413
The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
|
1 | P28330 (/ISS) |
Long-chain fatty acid catabolic process GO:0042758
The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22.
|
1 | P15650 (/IDA) |
Long-chain fatty acid catabolic process GO:0042758
The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22.
|
1 | P51174 (/ISO) |
Cellular lipid catabolic process GO:0044242
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
|
1 | P51174 (/IMP) |
Cellular lipid catabolic process GO:0044242
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
|
1 | P28330 (/ISS) |
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
1 | P51174 (/IMP) |
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
1 | P28330 (/ISS) |
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
|
1 | P51174 (/IMP) |
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
|
1 | P28330 (/ISS) |
Root hair elongation GO:0048767
The process in which the root hair grows longer.
|
1 | Q8RWZ3 (/IMP) |
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
1 | P15650 (/IDA) |
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
1 | P51174 (/ISO) |
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | P51174 (/IMP) |
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | P28330 (/ISS) |
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P51174 (/IMP) |
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P28330 (/ISS) |
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
1 | P51174 (/IMP) |
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
15 |
P96831 (/HDA)
P96831 (/HDA)
P96831 (/HDA)
P96831 (/HDA)
P96831 (/HDA)
P96831 (/HDA)
P96831 (/HDA)
P9WQG3 (/HDA)
P9WQG3 (/HDA)
P9WQG3 (/HDA)
(5 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
9 | P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) P96808 (/HDA) |
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
8 | P95280 (/HDA) P95280 (/HDA) P95280 (/HDA) P95280 (/HDA) P95280 (/HDA) P95280 (/HDA) P95280 (/HDA) P95280 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
5 | D3Z2B3 (/HDA) D3Z7X0 (/HDA) P51174 (/HDA) Q80XL6 (/HDA) Q8K370 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P15650 (/IDA) P51174 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | P28330 (/TAS) Q6JQN1 (/TAS) |
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
2 | Q709F0 (/ISS) Q80XL6 (/ISS) |
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
2 | P15650 (/IDA) Q709F0 (/IDA) |
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
2 | P51174 (/ISO) Q80XL6 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q709F0 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q80XL6 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P51174 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q6JQN1 (/NAS) |
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | Q709F0 (/TAS) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | P15650 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | P51174 (/ISO) |
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
1 | B3DMA2 (/IDA) |
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
1 | Q80XL6 (/ISO) |