The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cyclophilin-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Peptidyl-prolyl cis-trans isomerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
13 P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA)
(3 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
10 P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA)
Cyclosporin A binding GO:0016018
Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
10 P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
1 Q581Y2 (/ISM)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
1 Q54SM3 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q581Y2 (/IPI)
Cyclosporin A binding GO:0016018
Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
1 Q54SM3 (/ISS)
RRNA binding GO:0019843
Interacting selectively and non-covalently with ribosomal RNA.
1 Q581Y2 (/IDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
10 P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA)
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
10 P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
10 P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP)
Positive regulation of meiotic nuclear division GO:0045836
Any process that activates or increases the frequency, rate or extent of meiosis.
10 P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI) P14832 (/IGI)
Positive regulation of meiotic nuclear division GO:0045836
Any process that activates or increases the frequency, rate or extent of meiosis.
10 P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP) P14832 (/IMP)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
6 Q387G2 (/ISM) Q387G2 (/ISM) Q387G2 (/ISM) Q387G2 (/ISM) Q581Y2 (/ISM) Q94774 (/ISM)
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
1 Q54SM3 (/ISS)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
1 Q581Y2 (/IDA)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 Q54SM3 (/ISS)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q54SM3 (/IMP)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA)
(1 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
11 P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA) P14832 (/HDA)
(1 more)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
10 P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA)
Set3 complex GO:0034967
A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
10 P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA) P14832 (/IDA)
Set3 complex GO:0034967
A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
10 P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI) P14832 (/IPI)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q54SM3 (/IDA) Q6FVK5 (/IDA) Q6FVK5 (/IDA) Q94774 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q585R9 (/IDA) Q585R9 (/IDA) Q94774 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
7 Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q585R9 (/IDA) Q585R9 (/IDA) Q94774 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
7 Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q585R9 (/IDA) Q585R9 (/IDA) Q94774 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
5 Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q387G2 (/IDA) Q94774 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q585R9 (/IDA) Q585R9 (/IDA)
Yeast-form cell wall GO:0030445
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
2 P22011 (/IDA) P22011 (/IDA)
NADH dehydrogenase complex GO:0030964
An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.
2 Q585R9 (/IDA) Q585R9 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 P22011 (/IDA) P22011 (/IDA)
Contractile vacuole GO:0000331
A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.
1 Q585R7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P18253 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q581Y2 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q4QBH1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O02614 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P18253 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O02614 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 O02614 (/ISO)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
1 O02614 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9TW32 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 O02614 (/ISO)
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