CATH Superfamily 2.40.10.10

FunFam 387:

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term	Annotations	Evidence
Tissue kallikrein. [EC: 3.4.21.35] Preferential cleavage of Arg-\|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-\|-Xaa or Leu-\|-Xaa. Formed from tissue prokallikrein by activation with trypsin. A large number of tissue kallikrein-related sequences have been reported for rats and mice, though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse EC 3.4.21.54, submandibular proteinase a, epidermal growth- factor-binding protein, nerve growth factor gamma-subunit, rat tonin, submaxillary proteinases A and B, T-kininogenase, kallikreins K7 and K8. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-\|-Xaa bonds. Belongs to peptidase family S1. Formerly EC 3.4.21.8.	1	P15950

CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

Functional Families

FunFam 387:

There are 1 EC terms in this cluster