The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Atrial natriuretic peptide-converting enzyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
7 A1Z7D1 (/ISM) A1Z7D2 (/ISM) A8JUP7 (/ISM) O45029 (/ISM) Q4V3U8 (/ISM) Q9VWU1 (/ISM) Q9W1X6 (/ISM)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
4 P48740 (/IDA) P98064 (/IDA) Q8CHN8 (/IDA) Q9Y5Q5 (/IDA)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 Q9VWU1 (/IMP) Q9Z319 (/IMP)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 P98064 (/ISO) Q9Z319 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P48740 (/IDA) Q8CHN8 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P98064 (/ISS) Q8CHN8 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P48740 (/IPI) Q8CHN8 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
2 P48740 (/IPI) Q8CHN8 (/IPI)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Z319 (/ISS)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Y5Q5 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P98064 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P48740 (/IPI)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 P48740 (/IDA)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 Q9VWU1 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P98064 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P98064 (/ISS)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 P98064 (/ISO)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
6 A1Z7D2 (/ISM) A8JUP7 (/ISM) O45029 (/ISM) Q4V3U8 (/ISM) Q9VWU1 (/ISM) Q9W1X6 (/ISM)
Complement activation, lectin pathway GO:0001867
Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
2 P48740 (/IMP) P98064 (/IMP)
Regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
2 Q9Y5Q5 (/IMP) Q9Z319 (/IMP)
Regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
2 Q80YN4 (/ISS) Q9Y5Q5 (/ISS)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
2 Q9Y5Q5 (/IMP) Q9Z319 (/IMP)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 Q80YN4 (/IMP) Q9Z319 (/IMP)
Regulation of renal sodium excretion GO:0035813
Any process that modulates the amount of sodium excreted in urine over a unit of time.
2 Q80YN4 (/IMP) Q9Z319 (/IMP)
Complement activation, lectin pathway GO:0001867
Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
1 Q8CHN8 (/ISS)
Complement activation, lectin pathway GO:0001867
Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
1 P48740 (/TAS)
Positive regulation of antifungal peptide production GO:0002804
Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.
1 Q9VWU1 (/IMP)
Regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
1 Q9Z319 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q9VWU1 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 P48740 (/TAS)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
1 Q8CHN8 (/NAS)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
1 P48740 (/TAS)
Positive regulation of antibacterial peptide biosynthetic process GO:0006963
Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
1 Q9VWU1 (/IMP)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 Q9Z319 (/ISO)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 Q80YN4 (/ISS)
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
1 O45029 (/IDA)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 O45029 (/IMP)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 Q9Z319 (/ISO)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 Q9Y5Q5 (/ISS)
Regulation of Toll signaling pathway GO:0008592
Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
1 Q9VWU1 (/IGI)
Regulation of Toll signaling pathway GO:0008592
Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
1 Q9VWU1 (/IMP)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q9Y5Q5 (/IDA)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q9Z319 (/IMP)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q9Z319 (/ISO)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q80YN4 (/ISS)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q9Z319 (/ISO)
Regulation of melanization defense response GO:0035007
Any process that affects the rate, extent or location of the melanization defense response during injury or invasion.
1 A8JUP7 (/IMP)
Regulation of renal sodium excretion GO:0035813
Any process that modulates the amount of sodium excreted in urine over a unit of time.
1 Q9Z319 (/ISO)
Regulation of renal sodium excretion GO:0035813
Any process that modulates the amount of sodium excreted in urine over a unit of time.
1 Q9Y5Q5 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q9VWU1 (/IMP)
Positive regulation of Toll signaling pathway GO:0045752
Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.
1 Q9VWU1 (/IGI)
Positive regulation of Toll signaling pathway GO:0045752
Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.
1 Q9VWU1 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q9VWU1 (/IMP)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 Q9VWU1 (/IGI)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 Q9VWU1 (/IMP)
Antifungal innate immune response GO:0061760
An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q9VWU1 (/IMP)
Cellular response to molecule of bacterial origin GO:0071219
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
1 Q9VWU1 (/IMP)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
1 Q9Y5Q5 (/TAS)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A087X1D5 (/IDA) E7EQE7 (/IDA) J3KR88 (/IDA) J3KR90 (/IDA) Q9Y5Q5 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
5 A0A087X1D5 (/IDA) E7EQE7 (/IDA) J3KR88 (/IDA) J3KR90 (/IDA) Q9Y5Q5 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
5 A0A087X1D5 (/IDA) E7EQE7 (/IDA) J3KR88 (/IDA) J3KR90 (/IDA) Q9Y5Q5 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P48740 (/IDA) P98064 (/IDA) Q8CHN8 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9VWU1 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P48740 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P98064 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P48740 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P48740 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z319 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Y5Q5 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q80YN4 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9Z319 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9Z319 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q9Z319 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9Z319 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q80YN4 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q9Z319 (/ISO)
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