The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Trypsin-like serine proteases
".
FunFam 14: Complement factor D
There are 5 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
| EC Term | Annotations | Evidence |
|---|---|---|
|
Granzyme A.
[EC: 3.4.21.78]
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates.
|
9 | L8J1B0 L8J1B0 P11032 P11032 P12544 Q3U0N0 Q3U0N0 Q7YRZ7 Q7YRZ7 |
|
Chymase.
[EC: 3.4.21.39]
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
|
7 | P09650 P21842 P21844 P23946 P50339 P52195 P56435 |
|
Complement factor D.
[EC: 3.4.21.46]
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
|
6 | P00746 P03953 P03953 P32038 Q3UP47 Q3UP47 |
|
Granzyme B.
[EC: 3.4.21.79]
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.
|
6 | P04187 P04187 P10144 P18291 Q3TZH4 Q3TZH4 |
|
Cathepsin G.
[EC: 3.4.21.20]
Specificity similar to chymotrypsin C.
|
5 | P08311 P28293 P28293 Q059V7 Q059V7 |
