The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Trypsin-like serine proteases
".
FunFam 1: Periplasmic serine protease DegS
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
113 |
O53896 (/IMP)
O53896 (/IMP)
O53896 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
(103 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
112 |
O22609 (/IPI)
O22609 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
(102 more) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
112 |
O22609 (/IPI)
O22609 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
P0AEE3 (/IPI)
(102 more) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
111 |
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
(101 more) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
110 |
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
(100 more) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
110 |
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
(100 more) |
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
12 |
A0A0F7R9Y9 (/ISS)
A0A0F7R9Y9 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
(2 more) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
8 | Q607N4 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) |
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
5 | O22609 (/IDA) O22609 (/IDA) O53896 (/IDA) O53896 (/IDA) O53896 (/IDA) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
2 | O22609 (/IDA) O22609 (/IDA) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
2 | Q9LU10 (/IDA) Q9LU10 (/IDA) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
170 |
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
(160 more) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
112 |
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
(102 more) |
Cellular response to misfolded protein GO:0071218
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
|
111 |
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
(101 more) |
Cellular response to misfolded protein GO:0071218
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
|
110 |
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
(100 more) |
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
|
61 |
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
(51 more) |
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
57 |
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
D0ZY51 (/IMP)
(47 more) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
20 |
A0A0F7R9Y9 (/ISS)
A0A0F7R9Y9 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
A0A2B6C4K2 (/ISS)
(10 more) |
Photosystem II repair GO:0010206
Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition.
|
4 | O22609 (/IMP) O22609 (/IMP) Q9LU10 (/IMP) Q9LU10 (/IMP) |
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
3 | O53896 (/IDA) O53896 (/IDA) O53896 (/IDA) |
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
3 | O53896 (/IDA) O53896 (/IDA) O53896 (/IDA) |
Cellular response to antibiotic GO:0071236
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
3 | O53896 (/IMP) O53896 (/IMP) O53896 (/IMP) |
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
|
2 | O22609 (/IDA) O22609 (/IDA) |
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
2 | O22609 (/TAS) O22609 (/TAS) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
111 |
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
P0AEE4 (/ISS)
(101 more) |
Outer membrane-bounded periplasmic space GO:0030288
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
|
110 |
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
P0AEE3 (/IDA)
(100 more) |
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
110 |
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
P0AEE3 (/RCA)
(100 more) |
Integral component of external side of plasma membrane GO:0071575
The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane.
|
110 |
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
P0AEE3 (/IMP)
(100 more) |
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
5 | O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
5 | O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) O06291 (/HDA) |
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
|
4 | O22609 (/IDA) O22609 (/IDA) Q9LU10 (/IDA) Q9LU10 (/IDA) |
Chloroplast thylakoid GO:0009534
Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
|
4 | O22609 (/IDA) O22609 (/IDA) Q9LU10 (/IDA) Q9LU10 (/IDA) |
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
|
4 | O22609 (/IDA) O22609 (/IDA) Q9LU10 (/IDA) Q9LU10 (/IDA) |
Thylakoid lumen GO:0031977
The volume enclosed by a thylakoid membrane.
|
4 | O22609 (/IDA) O22609 (/IDA) Q9LU10 (/IDA) Q9LU10 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | O53896 (/HDA) O53896 (/HDA) O53896 (/HDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | O53896 (/IDA) O53896 (/IDA) O53896 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O22609 (/IDA) O22609 (/IDA) |
Chloroplast thylakoid membrane GO:0009535
The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
|
2 | O22609 (/IDA) O22609 (/IDA) |
Chloroplast thylakoid lumen GO:0009543
The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana.
|
2 | Q9LU10 (/IDA) Q9LU10 (/IDA) |