The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 73: SH3 and cysteine-rich domain-containing protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q6ZMT1 (/IPI) Q6ZMT1 (/IPI) Q8WUK8 (/IPI) Q99469 (/IPI) Q99469 (/IPI) Q99469 (/IPI)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
2 P97306 (/IPI) P97306 (/IPI)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of voltage-gated calcium channel activity GO:1901387
Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
6 A0JNJ1 (/ISS) Q6ZMT1 (/ISS) Q6ZMT1 (/ISS) Q99469 (/ISS) Q99469 (/ISS) Q99469 (/ISS)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
6 A0JNJ1 (/ISS) Q6ZMT1 (/ISS) Q6ZMT1 (/ISS) Q99469 (/ISS) Q99469 (/ISS) Q99469 (/ISS)
Positive regulation of cation channel activity GO:2001259
Any process that activates or increases the frequency, rate or extent of cation channel activity.
4 A0JNJ1 (/ISS) Q99469 (/ISS) Q99469 (/ISS) Q99469 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 Q99469 (/NAS) Q99469 (/NAS) Q99469 (/NAS)
Positive regulation of voltage-gated calcium channel activity GO:1901387
Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
3 P97306 (/IMP) P97306 (/IMP) Q8R1B0 (/IMP)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
3 P97306 (/IMP) P97306 (/IMP) Q8R1B0 (/IMP)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
2 P97306 (/IMP) P97306 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 P97306 (/IDA) P97306 (/IDA)
Regulation of voltage-gated calcium channel activity GO:1901385
Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
2 P97306 (/IMP) P97306 (/IMP)
Positive regulation of cation channel activity GO:2001259
Any process that activates or increases the frequency, rate or extent of cation channel activity.
2 P97306 (/IMP) P97306 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
6 A0JNJ1 (/ISS) Q6ZMT1 (/ISS) Q6ZMT1 (/ISS) Q99469 (/ISS) Q99469 (/ISS) Q99469 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q99469 (/NAS) Q99469 (/NAS) Q99469 (/NAS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
3 P97306 (/IDA) P97306 (/IDA) Q8R1B0 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
2 P97306 (/IDA) P97306 (/IDA)
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