The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"CCR4-NOT complex subunit 2/3/5, C-terminal domain
".
FunFam 1: Putative CCR4-NOT transcription complex subunit 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II transcription corepressor binding GO:0001226
Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.
|
37 |
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
(27 more) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
37 |
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
(27 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
37 |
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
Q9NZN8 (/IPI)
(27 more) |
|
RNA polymerase II transcription corepressor binding GO:0001226
Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
RNA polymerase II transcription corepressor binding GO:0001226
Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.
|
2 | Q8C5L3 (/ISS) Q8C5L3 (/ISS) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of stem cell population maintenance GO:2000036
Any process that modulates the frequency, rate or extent of stem cell population maintenance.
|
39 |
Q8C5L3 (/IMP)
Q8C5L3 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
(29 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
37 |
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
(27 more) |
|
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
|
37 |
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
(27 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
37 |
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
(27 more) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
37 |
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
(27 more) |
|
Positive regulation of cytoplasmic mRNA processing body assembly GO:0010606
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
37 |
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
(27 more) |
|
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
|
37 |
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
Q9NZN8 (/IMP)
(27 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8C5L3 (/ISS) Q8C5L3 (/ISS) |
|
Trophectodermal cell differentiation GO:0001829
The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
|
2 | Q8C5L3 (/IMP) Q8C5L3 (/IMP) |
|
Positive regulation of cytoplasmic mRNA processing body assembly GO:0010606
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
Positive regulation of cytoplasmic mRNA processing body assembly GO:0010606
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
2 | Q8C5L3 (/ISS) Q8C5L3 (/ISS) |
|
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
|
2 | Q8C5L3 (/ISS) Q8C5L3 (/ISS) |
|
Regulation of stem cell population maintenance GO:2000036
Any process that modulates the frequency, rate or extent of stem cell population maintenance.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
86 |
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
(76 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
86 |
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
(76 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
86 |
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
A0A024RBD8 (/IDA)
(76 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
37 |
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
Q9NZN8 (/NAS)
(27 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
37 |
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
(27 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
37 |
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
Q9NZN8 (/TAS)
(27 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
37 |
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
Q9NZN8 (/HDA)
(27 more) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
37 |
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
Q9NZN8 (/IDA)
(27 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q8C5L3 (/ISS) Q8C5L3 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
2 | Q8C5L3 (/ISO) Q8C5L3 (/ISO) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
2 | Q8C5L3 (/ISS) Q8C5L3 (/ISS) |
