The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: GRAM domain containing 1B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
8 Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR56 (/ISS) Q5RC33 (/ISS) Q8IYS0 (/ISS) Q96CP6 (/ISS)
Cholesterol transfer activity GO:0120020
Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
8 Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR56 (/ISS) Q5RC33 (/ISS) Q8IYS0 (/ISS) Q96CP6 (/ISS)
Sterol binding GO:0032934
Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
5 P38800 (/IDA) P38800 (/IDA) Q06681 (/IDA) Q06681 (/IDA) Q06681 (/IDA)
Sterol transfer activity GO:0120015
Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
5 P38800 (/IDA) P38800 (/IDA) Q06681 (/IDA) Q06681 (/IDA) Q06681 (/IDA)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
4 Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
4 Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
3 Q80TI0 (/IDA) Q8CI52 (/IDA) Q8VEF1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q8IYS0 (/IPI) Q96CP6 (/IPI)
Cholesterol transfer activity GO:0120020
Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
2 Q80TI0 (/IMP) Q8VEF1 (/IMP)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q80TI0 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q80TI0 (/IDA)
Cholesterol transfer activity GO:0120020
Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
1 Q8CI52 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
8 Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR56 (/ISS) Q5RC33 (/ISS) Q8IYS0 (/ISS) Q96CP6 (/ISS)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
4 Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS) Q3KR37 (/ISS)
Intracellular sterol transport GO:0032366
The directed movement of sterols within cells.
3 Q06681 (/IMP) Q06681 (/IMP) Q06681 (/IMP)
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
3 Q80TI0 (/IDA) Q8CI52 (/IDA) Q8VEF1 (/IDA)
Response to ethylene GO:0009723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.
2 F4HVW5 (/IMP) F4HVW5 (/IMP)
Response to salicylic acid GO:0009751
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.
2 F4HVW5 (/IMP) F4HVW5 (/IMP)
Intracellular sterol transport GO:0032366
The directed movement of sterols within cells.
2 P38800 (/IC) P38800 (/IC)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 F4HVW5 (/IMP) F4HVW5 (/IMP)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
2 F4HVW5 (/IMP) F4HVW5 (/IMP)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 Q80TI0 (/IMP)
Mitochondrion-endoplasmic reticulum membrane tethering GO:1990456
The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
1 O42976 (/ISO)
Vacuole-ER tethering GO:1990854
The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles.
1 O42976 (/ISO)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 A0A1D8PE20 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q80TI0 (/IDA) Q8CI52 (/IDA) Q8VEF1 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
7 Q3KR37 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q80TI0 (/IDA) Q8CI52 (/IDA) Q8VEF1 (/IDA)
Endoplasmic reticulum-plasma membrane contact site GO:0140268
A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.
7 Q3KR37 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q3KR37 (/IDA) Q80TI0 (/IDA) Q8CI52 (/IDA) Q8VEF1 (/IDA)
Cortical endoplasmic reticulum GO:0032541
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
5 P38800 (/IDA) P38800 (/IDA) Q06681 (/IDA) Q06681 (/IDA) Q06681 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O42976 (/HDA) Q06681 (/HDA) Q06681 (/HDA) Q06681 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 Q3KR37 (/HDA) Q3KR37 (/HDA) Q3KR37 (/HDA) Q3KR37 (/HDA)
Endoplasmic reticulum-plasma membrane contact site GO:0140268
A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.
4 Q3KR56 (/ISS) Q5RC33 (/ISS) Q8IYS0 (/ISS) Q96CP6 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q06681 (/IDA) Q06681 (/IDA) Q06681 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
3 Q3KR56 (/ISS) Q5RC33 (/ISS) Q8IYS0 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q3KR56 (/ISS) Q5RC33 (/ISS) Q8IYS0 (/ISS)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
3 Q06681 (/HDA) Q06681 (/HDA) Q06681 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P38800 (/HDA) P38800 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 F4HVW5 (/IDA) F4HVW5 (/IDA)
Organelle membrane contact site GO:0044232
A zone of apposition between the membranes of an organelle with another membrane, either that of another organelle or the plasma membrane, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
2 Q3KR56 (/ISS) Q8VEF1 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q80TI0 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q80TI0 (/ISO)
Intrinsic component of endoplasmic reticulum membrane GO:0031227
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q96CP6 (/IDA)
Intrinsic component of endoplasmic reticulum membrane GO:0031227
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q8VEF1 (/ISO)
Intrinsic component of endoplasmic reticulum membrane GO:0031227
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q8VEF1 (/ISS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q96CP6 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q8VEF1 (/ISO)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q8VEF1 (/ISS)
Organelle membrane contact site GO:0044232
A zone of apposition between the membranes of an organelle with another membrane, either that of another organelle or the plasma membrane, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
1 Q96CP6 (/IDA)
Organelle membrane contact site GO:0044232
A zone of apposition between the membranes of an organelle with another membrane, either that of another organelle or the plasma membrane, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
1 Q8VEF1 (/ISO)
Mitochondria-associated endoplasmic reticulum membrane GO:0044233
A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
1 O42976 (/ISO)
Nucleus-vacuole junction GO:0071561
An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.
1 O42976 (/ISO)
Endoplasmic reticulum-plasma membrane contact site GO:0140268
A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.
1 Q80TI0 (/ISO)
Vacuole-mitochondrion membrane contact site GO:1990816
A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles.
1 O42976 (/ISO)