CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 411: Blast:Rho GTPase-activating protein 26
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
3 | Q86NY4 (/ISM) Q9VXQ2 (/ISM) X2JDY8 (/ISM) |
|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
3 | Q86NY4 (/ISS) Q9VXQ2 (/ISS) X2JDY8 (/ISS) |
|
Ubiquitin-dependent protein binding GO:0140036
Interacting selectively and non-covalently with a protein upon ubiquitination of the target protein.
|
1 | X2JDY8 (/IDA) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
3 | Q86NY4 (/ISM) Q9VXQ2 (/ISM) X2JDY8 (/ISM) |
|
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
|
1 | X2JDY8 (/IMP) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | X2JDY8 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | X2JDY8 (/IDA) |