The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SRA-YDG
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Histone-lysine N-methyltransferase, H3 lysine-9 sp...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O22781 (/IPI) Q8GZB6 (/IPI) Q8VZ17 (/IPI) Q9T0G7 (/IPI) Q9T0G7 (/IPI)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
5 O22781 (/ISS) O82175 (/ISS) O82175 (/ISS) Q9C5P0 (/ISS) Q9C5P4 (/ISS)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q9FF80 (/IDA) Q9FF80 (/IDA)
Methyl-CpG binding GO:0008327
Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
2 Q8GZB6 (/IDA) Q8VZ17 (/IDA)
Methyl-CpNpG binding GO:0010428
Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide.
2 Q8GZB6 (/IDA) Q8VZ17 (/IDA)
Methyl-CpNpN binding GO:0010429
Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide.
2 Q8GZB6 (/IDA) Q8VZ17 (/IDA)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
2 Q9FF80 (/IDA) Q9FF80 (/IDA)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
2 O82175 (/IDA) O82175 (/IDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 Q8VZ17 (/IDA)
Double-stranded methylated DNA binding GO:0010385
Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
1 Q8GZB6 (/IDA)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q8GZB6 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
7 O22781 (/TAS) O82175 (/TAS) O82175 (/TAS) Q9C5P0 (/TAS) Q9C5P4 (/TAS) Q9FF80 (/TAS) Q9FF80 (/TAS)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
5 O22781 (/IDA) O82175 (/IDA) O82175 (/IDA) Q8GZB6 (/IDA) Q8VZ17 (/IDA)
RNA-directed DNA methylation GO:0080188
An epigenetic RNA-based gene silencing process first elucidated in plants whereby 24-nt small interfering RNAs (siRNAs) guide DNA methyltransferases to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci.
3 O22781 (/IMP) Q9T0G7 (/IMP) Q9T0G7 (/IMP)
DNA mediated transformation GO:0009294
The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material.
2 Q9T0G7 (/IMP) Q9T0G7 (/IMP)
Response to chitin GO:0010200
A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus.
2 O82175 (/IEP) O82175 (/IEP)
Chromatin silencing by small RNA GO:0031048
Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region.
2 O82175 (/IEP) O82175 (/IEP)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
1 Q9C5P0 (/IMP)
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
1 Q8GZB6 (/IDA)
Peptidyl-lysine methylation GO:0018022
The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.
1 Q8GZB6 (/IDA)
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
1 O22781 (/IMP)
Leaf development GO:0048366
The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
1 Q9C5P0 (/IMP)
Histone H3-K9 methylation GO:0051567
The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.
1 Q8GZB6 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 O22781 (/IDA) Q9C5P4 (/IDA) Q9FF80 (/IDA) Q9FF80 (/IDA)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
1 Q9C5P4 (/IDA)
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
1 O22781 (/IDA)