The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Head domain of nucleotide exchange factor GrpE
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Protein GrpE

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 C4ZYN1 (/IPI) C4ZYN1 (/IPI) C4ZYN1 (/IPI) C4ZYN1 (/IPI) C4ZYN1 (/IPI) P09372 (/IPI) P09372 (/IPI) P09372 (/IPI) P09372 (/IPI) P09372 (/IPI)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
5 P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
5 P09372 (/IMP) P09372 (/IMP) P09372 (/IMP) P09372 (/IMP) P09372 (/IMP)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
5 P09372 (/IPI) P09372 (/IPI) P09372 (/IPI) P09372 (/IPI) P09372 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
3 Q9C8X4 (/IDA) Q9XQC7 (/IDA) Q9XQC7 (/IDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
3 Q8IIB6 (/ISS) Q8IIB6 (/ISS) Q8IIB6 (/ISS)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
1 Q54QF9 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
6 O30862 (/ISS) O30862 (/ISS) O30862 (/ISS) O30862 (/ISS) O30862 (/ISS) O30862 (/ISS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
5 P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
5 P09372 (/IEP) P09372 (/IEP) P09372 (/IEP) P09372 (/IEP) P09372 (/IEP)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
5 P09372 (/IMP) P09372 (/IMP) P09372 (/IMP) P09372 (/IMP) P09372 (/IMP)
Protein import into mitochondrial matrix GO:0030150
The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
3 Q8IIB6 (/TAS) Q8IIB6 (/TAS) Q8IIB6 (/TAS)
Protein import into mitochondrial matrix GO:0030150
The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
1 Q54QF9 (/ISS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P09372 (/HDA) P09372 (/HDA) P09372 (/HDA) P09372 (/HDA) P09372 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA) P09372 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q54QF9 (/ISS) Q8IIB6 (/ISS) Q8IIB6 (/ISS) Q8IIB6 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 Q54QF9 (/ISS) Q8IIB6 (/ISS) Q8IIB6 (/ISS) Q8IIB6 (/ISS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 Q9C8X4 (/IDA) Q9XQC7 (/IDA) Q9XQC7 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
3 Q9C8X4 (/IDA) Q9XQC7 (/IDA) Q9XQC7 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
2 Q9XQC7 (/IDA) Q9XQC7 (/IDA)
PAM complex, Tim23 associated import motor GO:0001405
Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.
1 Q54QF9 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q18421 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q584T9 (/RCA)
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