The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transcription factor IIA (TFIIA), beta-barrel domain
".
FunFam 7: TOA1p TFIIA large subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
8 | P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
8 | P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
8 | P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
8 | P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) P32773 (/IPI) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
8 | P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) |
|
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
|
8 | P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) |
|
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
|
8 | P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) P32773 (/IGI) |
|
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
|
8 | P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
8 | P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) P32773 (/IDA) |
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
8 | P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) P32773 (/IMP) |