The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transcription factor IIA (TFIIA), beta-barrel domain
".
FunFam 2: Transcription initiation factor IIA subunit 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
17 |
P52654 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
(7 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
14 |
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
(4 more) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
13 |
P52654 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
(3 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
12 |
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(2 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
12 |
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
(2 more) |
|
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
|
12 |
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(2 more) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
12 |
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
P52655 (/IPI)
(2 more) |
|
TFIID-class transcription factor complex binding GO:0001094
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
|
1 | P52654 (/IPI) |
|
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
1 | Q99PM3 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q99PM3 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q99PM3 (/ISO) |
|
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
|
1 | Q99PM3 (/ISO) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
1 | Q99PM3 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q99PM3 (/ISO) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
14 |
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
(4 more) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
13 |
P52654 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(3 more) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
12 |
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
(2 more) |
|
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
|
12 |
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
(2 more) |
|
Cognition GO:0050890
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
|
2 | Q9UNN4 (/IMP) Q9UNN4 (/IMP) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
1 | Q99PM3 (/ISO) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
1 | P52654 (/ISS) |
|
Cognition GO:0050890
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
|
1 | Q8R4I4 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
15 |
P52654 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(5 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(2 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
P52655 (/TAS)
(2 more) |
|
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
12 |
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(2 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
12 |
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
P52655 (/IDA)
(2 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P52654 (/IDA) Q8R4I4 (/IDA) Q99PM3 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q8R4I4 (/IDA) Q99PM3 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q99PM3 (/ISO) |
|
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
1 | Q99PM3 (/ISO) |
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
1 | Q99PM3 (/ISO) |
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
1 | P52654 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q99PM3 (/ISO) |
