The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transcription factor IIA (TFIIA), beta-barrel domain
".
FunFam 1: Transcription initiation factor IIA subunit 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
55 |
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
O08950 (/IPI)
(45 more) |
|
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
|
46 |
O74948 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(36 more) |
|
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
45 |
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
Q80ZM7 (/IPI)
(35 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
12 |
P52656 (/IPI)
P52656 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
P52657 (/IPI)
(2 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
10 | P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) |
|
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
|
10 | P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
10 | P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
10 | P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) P52657 (/IPI) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
47 |
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
O08950 (/IMP)
(37 more) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
12 |
P52656 (/IDA)
P52656 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
(2 more) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
10 | P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
10 | P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) |
|
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
|
10 | P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
10 | P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
10 | P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) |
|
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
|
10 | P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
3 | P52656 (/ISS) P52656 (/ISS) Q54ND1 (/ISS) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
1 | O74948 (/ISO) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
46 |
O74948 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(36 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
45 |
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
Q80ZM7 (/ISO)
(35 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
20 |
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
(10 more) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
20 |
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
A0A024R5Z5 (/IDA)
(10 more) |
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
12 |
P52656 (/IDA)
P52656 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
P52657 (/IDA)
(2 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
10 | P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) P52657 (/TAS) |
|
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
10 | P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) P52657 (/IDA) |
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
3 | P52656 (/ISS) P52656 (/ISS) Q54ND1 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P52656 (/IDA) P52656 (/IDA) |
|
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
|
2 | P52656 (/IPI) P52656 (/IPI) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O74948 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O74948 (/HDA) |
