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CATH Superfamily 2.20.70.30

Nascent polypeptide-associated complex domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nascent polypeptide-associated complex domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nascent polypeptide-associated complex domain

Structural domains comprising this superfamily share the structure of the nascent polypeptide-associated complex (NAC) domain, which mediates dimerization of the two subunits, alpha-NAC (NACA) and beta-NAC (BTF3), that make up the eukaryotic NAC heterodimer PMID:21203952. NAC is a cytosolic chaperone that contact nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes. In addition to acting as a protein translation chaperone, the individual NAC subunits are also involved in transcriptional regulation PMID:20214399.

GO Diversity

Unique GO annotations
53 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
2289 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 7
Function
Unique EC:
Unique GO: 53
Taxonomy
Unique Species: 2289