The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
RNA polymerase ii, chain L
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: DNA-directed RNA polymerases I, II, and III subuni...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase I activity GO:0001054
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription by RNA polymerase I GO:0006360
The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)
Transcription by RNA polymerase I GO:0006360
The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
9 P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
9 P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
9 P40422 (/IGI) P40422 (/IGI) P40422 (/IGI) P40422 (/IGI) P40422 (/IGI) P40422 (/IGI) P40422 (/IGI) P40422 (/IGI) P40422 (/IGI)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
9 P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP) P40422 (/IMP)
Termination of RNA polymerase III transcription GO:0006386
The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues.
9 P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS)
TRNA transcription by RNA polymerase III GO:0042797
The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS) P40422 (/TAS)
RNA polymerase II, core complex GO:0005665
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)
RNA polymerase III complex GO:0005666
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
9 P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA)
RNA polymerase I complex GO:0005736
RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
9 P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA) P40422 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA) P40422 (/HDA)
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