The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: DNA helicase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
15 Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS)
(5 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 F4KAB8 (/IPI) F4KAB8 (/IPI) P29458 (/IPI) P30665 (/IPI) P30665 (/IPI) P30665 (/IPI) P33991 (/IPI) P49717 (/IPI) P49717 (/IPI) P49731 (/IPI)
(5 more)
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
15 Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS)
(5 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
6 P29458 (/IDA) P30664 (/IDA) P30664 (/IDA) Q5XK83 (/IDA) Q6NZV2 (/IDA) Q6PHK9 (/IDA)
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
4 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
3 P30665 (/IMP) P30665 (/IMP) P30665 (/IMP)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
2 P49717 (/IPI) P49717 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q382V6 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q382V6 (/ISM)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 Q382V6 (/IDA)
Single-stranded DNA helicase activity GO:0017116
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.
1 P53091 (/IDA)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
15 Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS) Q8IDF0 (/ISS)
(5 more)
DNA unwinding involved in DNA replication GO:0006268
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
6 P30664 (/IDA) P30664 (/IDA) P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA)
Double-strand break repair via break-induced replication GO:0000727
The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
4 P30665 (/IMP) P30665 (/IMP) P30665 (/IMP) P53091 (/IMP)
Pre-replicative complex assembly involved in nuclear cell cycle DNA replication GO:0006267
The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation.
4 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA)
DNA unwinding involved in DNA replication GO:0006268
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
4 F4KAB8 (/TAS) F4KAB8 (/TAS) Q0WVF5 (/TAS) Q0WVF5 (/TAS)
DNA strand elongation involved in DNA replication GO:0006271
The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
4 P30665 (/IMP) P30665 (/IMP) P30665 (/IMP) P53091 (/IMP)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
3 P33991 (/TAS) Q26454 (/TAS) Q26454 (/TAS)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
3 P30665 (/IGI) P30665 (/IGI) P30665 (/IGI)
Regulation of DNA-dependent DNA replication initiation GO:0030174
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
3 P30664 (/IDA) P30664 (/IDA) Q5XK83 (/IDA)
Nuclear DNA replication GO:0033260
The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
3 P30665 (/IMP) P30665 (/IMP) P30665 (/IMP)
Response to yeast GO:0001878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
2 Q6NZV2 (/IDA) Q6PHK9 (/IDA)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
2 Q26454 (/IMP) Q26454 (/IMP)
DNA unwinding involved in DNA replication GO:0006268
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2 P49717 (/IPI) P49717 (/IPI)
DNA unwinding involved in DNA replication GO:0006268
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2 Q5XK83 (/ISS) Q6GL41 (/ISS)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
2 Q26454 (/IMP) Q26454 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
2 Q0WVF5 (/IMP) Q0WVF5 (/IMP)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
1 Q95XQ8 (/IMP)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
1 P33991 (/TAS)
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
1 P49731 (/IMP)
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
1 P49731 (/IPI)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
1 P33991 (/NAS)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
1 Q382V6 (/IDA)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
1 Q382V6 (/ISA)
Premeiotic DNA replication GO:0006279
The replication of DNA that precedes meiotic cell division.
1 P49731 (/IC)
Premeiotic DNA replication GO:0006279
The replication of DNA that precedes meiotic cell division.
1 P29458 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q95XQ8 (/IMP)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
1 Q95XQ8 (/IMP)
Regulation of DNA-dependent DNA replication initiation GO:0030174
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
1 Q6GL41 (/ISS)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 Q95XQ8 (/IMP)
Cell cycle DNA replication GO:0044786
The DNA-dependent DNA replication that takes place as part of the cell cycle.
1 Q382V6 (/IDA)
Replication fork protection GO:0048478
Any process that prevents the collapse of stalled replication forks.
1 P29458 (/IMP)
Mitotic DNA replication GO:1902969
Any nuclear DNA replication that is involved in a mitotic cell cycle.
1 P49731 (/IMP)
Mitotic DNA replication initiation GO:1902975
Any DNA replication initiation involved in mitotic cell cycle DNA replication.
1 P29458 (/IMP)
Mitotic DNA replication initiation GO:1902975
Any DNA replication initiation involved in mitotic cell cycle DNA replication.
1 P49731 (/TAS)
Negative regulation of DNA helicase activity GO:1905775
Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity.
1 P29458 (/IMP)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MCM complex GO:0042555
A hexameric protein complex required for the initiation and regulation of DNA replication.
11 P29458 (/IDA) P30664 (/IDA) P30664 (/IDA) P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P33991 (/IDA) P49731 (/IDA) P53091 (/IDA) Q382V6 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P29458 (/IDA) P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P49731 (/IDA) P53091 (/IDA) Q382V6 (/IDA) Q95XQ8 (/IDA)
MCM core complex GO:0097373
A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated.
6 P29458 (/IDA) P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P49731 (/IDA) P53091 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 P30665 (/TAS) P30665 (/TAS) P30665 (/TAS) P33991 (/TAS) P53091 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA) Q382V6 (/IDA)
MCM complex GO:0042555
A hexameric protein complex required for the initiation and regulation of DNA replication.
5 P49717 (/ISS) P49717 (/ISS) Q6GL41 (/ISS) Q86B14 (/ISS) Q86IF1 (/ISS)
CMG complex GO:0071162
A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
5 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA) Q382V6 (/IDA)
THO complex GO:0000347
The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
4 F4KAB8 (/IDA) F4KAB8 (/IDA) Q0WVF5 (/IDA) Q0WVF5 (/IDA)
Nuclear pre-replicative complex GO:0005656
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
4 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA)
DNA replication preinitiation complex GO:0031261
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
4 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA)
Replication fork protection complex GO:0031298
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.
4 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA) P53091 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
3 P30664 (/IDA) P30664 (/IDA) Q5XK83 (/IDA)
Nuclear replication fork GO:0043596
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
3 P30665 (/IDA) P30665 (/IDA) P30665 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P29458 (/IDA) P49731 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P33991 (/IDA) Q382V6 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P49717 (/ISO) P49717 (/ISO)
Nuclear pre-replicative complex GO:0005656
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
2 P29458 (/IC) P49731 (/IC)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q0WVF5 (/IDA) Q0WVF5 (/IDA)
DNA replication preinitiation complex GO:0031261
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
2 P29458 (/IC) P49731 (/IC)
MCM complex GO:0042555
A hexameric protein complex required for the initiation and regulation of DNA replication.
2 P49717 (/ISO) P49717 (/ISO)
Nuclear replication fork GO:0043596
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
2 P29458 (/IC) P49731 (/IC)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 P33991 (/HDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q6GL41 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P33991 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P49731 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P33991 (/HDA)
RDNA protrusion GO:0030875
Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.
1 P29458 (/IDA)
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