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CATH Superfamily 2.20.25.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 70: Terminal oxygenase component of carbazole

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carbazole 1,9a-dioxygenase. [EC: 1.14.12.22]
9H-carbazole + NAD(P)H + O(2) = 2'-aminobiphenyl-2,3-diol + NAD(P)(+).
  • This enzyme catalyzes the first reaction in the pathway of carbazole degradation.
  • The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2'-aminobiphenyl-2,3-diol.
  • In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase.
  • The terminal oxygenase component contains a nonheme iron center and a Rieske [2Fe-2S] iron-sulfur cluster.
 17 B7XGE8 B7XGE8 B7XGE8 B7XGE8 D5IGG0 O34807 O34807 O34807 O34807 Q8G8B6
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